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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Histopathological and bacteriological findings in prurigo nodularis.

Prurigo nodularis is a chronic disease with unknown aetiology. Biopsy specimens of 43 patients with prurigo nodularis were taken for histopathological and mycobacteriological analyses. By conventional histopathology, 25 (58%) samples, and by immunostaining for S100 protein, 31 (72%) samples had changes relevant to prurigo nodularis. Twelve (28%) of the samples were positive for acid fast bacilli in tissue staining by Ziehl-Neelsen technique, including 4 of the 6 samples also positive for mycobacteria in cultivation. The results verified the usefulness of S100 staining in detection of neural hyperplasia in dermal nerves, a feature regarded as diagnostic for prurigo nodularis. They also indicated that atypical mycobacteria may be a contributing factor in prurigo nodularis.[1]


  1. Histopathological and bacteriological findings in prurigo nodularis. Mattila, J.O., Vornanen, M., Katila, M.L. Acta Derm. Venereol. (1997) [Pubmed]
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