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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Prurigo

  • Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity [1].
  • Increased numbers of calcitonin gene-related peptide (CGRP) and substance P immunoreactive nerve fibre bundles were detected in specimens taken from prurigo nodularis lesions, but no increased immunoreactivity could be seen in specimens taken from patients having neurodermatitis circumscripta compared to normal skin [2].
  • OBJECTIVE: To evaluate safety and efficacy of thalidomide in the treatment of prurigo nodularis in a group of human immunodeficiency virus (HIV)-infected patients whose condition was recalcitrant to standard treatment [3].
  • Dermatologic disorders in addition to ENL in which thalidomide's effectiveness is well documented include aphthous stomatitis, discoid lupus erythematosus, actinic prurigo, Behçet's disease, and prurigo nodularis [4].
  • The results verified the usefulness of S100 staining in detection of neural hyperplasia in dermal nerves, a feature regarded as diagnostic for prurigo nodularis [5].

High impact information on Prurigo

  • Prurigo nodularis and aluminium overload in maintenance haemodialysis [6].
  • Highest IL-31 levels were detected in prurigo nodularis, one of the most pruritic forms of chronic skin inflammation [7].
  • Thalidomide treatment for prurigo nodularis in human immunodeficiency virus-infected subjects: efficacy and risk of neuropathy [3].
  • Moreover, the points of chronic eruptions such as lichenification and prurigo were significantly higher in the patients with elevated TIMP-1 levels than those with normal TIMP-1, while those of acute lesions such as oozy/microvesicles and oedema were not different between these groups [8].
  • CONCLUSION: Topical treatment of prurigo nodularis with capsaicin proved to be an effective and safe regimen resulting in clearing of the skin lesions [9].

Chemical compound and disease context of Prurigo


Anatomical context of Prurigo


Gene context of Prurigo

  • The involvement of keratinocytes in the pathogenesis of actinic prurigo is suggested by the expression of ICAM-1 on these cells [19].
  • The absence of significant changes in lichenified skin suggests that the increase in CGRP- and SP-immunoreactive nerve fibres is a characteristic feature of nodular prurigo and may be important in its pathogenesis [20].
  • The immunoreactivity of ECP and EDN/EPX in prurigo lesional skin was stronger than in uninvolved skin or control skin [18].
  • In prurigo nodularis lesional skin, the ECP- and EDN/EPX-containing cells, which were mainly distributed in the upper dermis, were significantly increased in number compared to their numbers in uninvolved and normal skin [18].
  • Multifocal hepatocellular carcinoma presenting as prurigo: two cases [21].

Analytical, diagnostic and therapeutic context of Prurigo


  1. Augmentation of ultraviolet erythema by indomethacin in actinic prurigo: evidence of mechanism of photosensitivity. Farr, P.M., Diffey, B.L. Photochem. Photobiol. (1988) [Pubmed]
  2. Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. Vaalasti, A., Suomalainen, H., Rechardt, L. Br. J. Dermatol. (1989) [Pubmed]
  3. Thalidomide treatment for prurigo nodularis in human immunodeficiency virus-infected subjects: efficacy and risk of neuropathy. Maurer, T., Poncelet, A., Berger, T. Archives of dermatology. (2004) [Pubmed]
  4. Thalidomide and its impact in dermatology. Stirling, D.I. Seminars in cutaneous medicine and surgery. (1998) [Pubmed]
  5. Histopathological and bacteriological findings in prurigo nodularis. Mattila, J.O., Vornanen, M., Katila, M.L. Acta Derm. Venereol. (1997) [Pubmed]
  6. Prurigo nodularis and aluminium overload in maintenance haemodialysis. Brown, M.A., George, C.R., Dunstan, C.R., Kalowski, S., Corrigan, A.B. Lancet (1992) [Pubmed]
  7. IL-31: a new link between T cells and pruritus in atopic skin inflammation. Sonkoly, E., Muller, A., Lauerma, A.I., Pivarcsi, A., Soto, H., Kemeny, L., Alenius, H., Dieu-Nosjean, M.C., Meller, S., Rieker, J., Steinhoff, M., Hoffmann, T.K., Ruzicka, T., Zlotnik, A., Homey, B. J. Allergy Clin. Immunol. (2006) [Pubmed]
  8. Increased levels of serum tissue inhibitor of metalloproteinase-1 but not metalloproteinase-3 in atopic dermatitis. Katoh, N., Hirano, S., Suehiro, M., Ikenaga, K., Yasuno, H. Clin. Exp. Immunol. (2002) [Pubmed]
  9. Treatment of prurigo nodularis with topical capsaicin. Ständer, S., Luger, T., Metze, D. J. Am. Acad. Dermatol. (2001) [Pubmed]
  10. Treatment of nodular prurigo with cyclosporin (treat the disease, not just the symptoms). Koblenzer, C.S. Br. J. Dermatol. (1996) [Pubmed]
  11. Prurigo pigmentosa treated with minocycline. Schepis, C., Siragusa, M., Palazzo, R., Ussia, A.F., Cavallari, V. Br. J. Dermatol. (1996) [Pubmed]
  12. Etretinate and nodular prurigo. Rowland Payne, C.M. Br. J. Dermatol. (1988) [Pubmed]
  13. Thalidomide: use and possible mode of action in reactional lepromatous leprosy and in various other conditions. Barnhill, R.L., McDougall, A.C. J. Am. Acad. Dermatol. (1982) [Pubmed]
  14. Demonstration by S-100 protein staining of increased numbers of nerves in the papillary dermis of patients with prurigo nodularis. Harris, B., Harris, K., Penneys, N.S. J. Am. Acad. Dermatol. (1992) [Pubmed]
  15. Pemphigoid nodularis. Tani, M., Murata, Y., Masaki, H. J. Am. Acad. Dermatol. (1989) [Pubmed]
  16. Histamine-containing mast cells and their relationship to NGFr-immunoreactive nerves in prurigo nodularis: a reappraisal. Liang, Y., Marcusson, J.A., Jacobi, H.H., Haak-Frendscho, M., Johansson, O. J. Cutan. Pathol. (1998) [Pubmed]
  17. Langerhans cells in prurigo nodularis investigated by HLA-DR and S-100 immunofluorescence double staining. Johansson, O., Liang, Y., Heilborn, J.D., Marcusson, J.A. J. Dermatol. Sci. (1998) [Pubmed]
  18. Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis. Johansson, O., Liang, Y., Marcusson, J.A., Reimert, C.M. Arch. Dermatol. Res. (2000) [Pubmed]
  19. An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light. Torres-Alvarez, B., Baranda, L., Fuentes, C., Delgado, C., Santos-Martinez, L., Portales-Perez, D., Moncada, B., Gonzalez-Amaro, R. European journal of dermatology : EJD. (1998) [Pubmed]
  20. Increased sensory neuropeptides in nodular prurigo: a quantitative immunohistochemical analysis. Abadía Molina, F., Burrows, N.P., Jones, R.R., Terenghi, G., Polak, J.M. Br. J. Dermatol. (1992) [Pubmed]
  21. Multifocal hepatocellular carcinoma presenting as prurigo: two cases. Dereure, O., Guilhou, J.J. Br. J. Dermatol. (2000) [Pubmed]
  22. Successful interferon alpha therapy in atopic dermatitis of Besnier's prurigo pattern with normal serum IgE and blood eosinophil fraction: randomized case-controlled study. Noh, G., Lee, K.Y. Cytokine (2001) [Pubmed]
  23. Treatment of prurigo nodularis: use of cryosurgery and intralesional steroids plus lidocaine. Stoll, D.M., Fields, J.P., King, L.E. The Journal of dermatologic surgery and oncology. (1983) [Pubmed]
  24. In vivo measurements of iron, copper and zinc in the skin of prurigo nodularis patients treated with thalidomide. Sheskin, J., Gorodetzky, R., Loewinger, E., Weinreb, A. Dermatologica (1981) [Pubmed]
  25. Dendritic mast cells in prurigo nodularis skin. Liang, Y., Jacobi, H.H., Marcusson, J.A., Haak-Frendscho, M., Johansson, O. European journal of dermatology : EJD. (1999) [Pubmed]
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