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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Postnatal developmental changes of neurons expressing calcium-binding proteins and GAD mRNA in the pretectal nuclear complex of the cat.

The postnatal development of the cat pretectum has been analysed with in situ hybridization and immunohistochemistry with the aim to establish the time course of morphological and neurochemical maturation of parvalbumin (PARV), calbindin-D28k (CALB), and glutamic acid decarboxylase (GAD) expressing neuronal populations. At birth, PARV-ir retinal afferents to the pretectum have already formed distinct termination zones which appear as 3 clusters separated by intercluster regions in coronal sections. The clusters contain two sets of large neurons expressing either PARV or CALB. The two sets of neurons differ in the time at which they grow rapidly. Both sets reach the adult size at P38. PARV-ir retinal fibers contact dendrites of large PARV-negative, and thus presumably CALB-ir neurons. A population of smaller CALB-ir neurons appears within the clusters during the second postnatal week. In intercluster regions, small PARV-ir and CALB-ir neurons are present at birth, but increase in number during development. Only PARV-ir intercluster neurons increase in size between P4 and P38. GAD neurons are present dorsal to the clusters and in intercluster regions from P0 onwards. However, within the clusters GAD neurons do not appear until the second postnatal week. The different onset of marker expression and cellular growth patterns suggest the existence of several populations of CaBP-ir excitatory and inhibitory neurons in the pretectum. The final complement of inhibitory neurons is not present until the second postnatal week. These developmental processes may correlate with the slow maturation of the pretectal motion processing system and the cortico-pretectal projection.[1]


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