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Gene Review

GAD1  -  glutamate decarboxylase 1 (brain, 67kDa)

Felis catus

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Biological context of GAD1


Anatomical context of GAD1


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Analytical, diagnostic and therapeutic context of GAD1

  • Dual-color immunofluorescence revealed that focal accumulations of beta 2/beta 3-subunit immunoreactivity were frequently apposed by glutamic acid decarboxylase (GAD)-immunoreactive terminals [20].
  • Immunocytochemical localization of glutamic acid decarboxylase (GAD) and glutamine synthetase (GS) in the area postrema of the cat. Light and electron microscopy [21].
  • Western blot analysis showed that the expression of both GAD67 and GAD65 increased to approximately two-thirds of the adult level during the first 5 postnatal weeks and gradually increased thereafter [22].


  1. Action and localization of gamma-aminobutyric acid in the cat retina. Bolz, J., Frumkes, T., Voigt, T., Wässle, H. J. Physiol. (Lond.) (1985) [Pubmed]
  2. Alterations in expression of messenger RNAs encoding two isoforms of glutamic acid decarboxylase in the globus pallidus and entopeduncular nucleus in animals symptomatic for and recovered from experimental Parkinsonism. Schroeder, J.A., Schneider, J.S. Brain Res. (2001) [Pubmed]
  3. Evidence that wakefulness and REM sleep are controlled by a GABAergic pontine mechanism. Xi, M.C., Morales, F.R., Chase, M.H. J. Neurophysiol. (1999) [Pubmed]
  4. Monoclonal antibody that identifies subsets of neurones in the central visual system of monkey and cat. Hendry, S.H., Hockfield, S., Jones, E.G., McKay, R. Nature (1984) [Pubmed]
  5. Visual experience regulates gene expression in the developing striate cortex. Neve, R.L., Bear, M.F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. Heterogeneity of GABAergic cells in cat visual cortex. Demeulemeester, H., Vandesande, F., Orban, G.A., Brandon, C., Vanderhaeghen, J.J. J. Neurosci. (1988) [Pubmed]
  7. Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein. Kobayashi, Y., Kaufman, D.L., Tobin, A.J. J. Neurosci. (1987) [Pubmed]
  8. The morphogenesis of glutamic acid decarboxylase in the neostriatum of the cat: neuronal and ultrastructural localization. Fisher, R.S., Levine, M.S., Adinolfi, A.M., Hull, C.D., Buchwald, N.A. Brain Res. (1987) [Pubmed]
  9. Peripheral nerve stimulation increases Fos immunoreactivity without affecting type II Ca2+/calmodulin-dependent protein kinase, glutamic acid decarboxylase, or GABAA receptor gene expression in cat spinal cord. Liang, F., Jones, E.G. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1996) [Pubmed]
  10. A description of the GABAergic neurons and axon terminals in the motor nuclei of the cat thalamus. Kultas-Ilinsky, K., Ribak, C.E., Peterson, G.M., Oertel, W.H. J. Neurosci. (1985) [Pubmed]
  11. Glutamic acid decarboxylase-immunoreactive neurons and horseradish peroxidase-labeled projection neurons in the ventral posterior nucleus of the cat and Galago senegalensis. Penny, G.R., Fitzpatrick, D., Schmechel, D.E., Diamond, I.T. J. Neurosci. (1983) [Pubmed]
  12. The morphology of physiologically identified GABAergic neurons in the somatic sensory part of the thalamic reticular nucleus in the cat. Yen, C.T., Conley, M., Hendry, S.H., Jones, E.G. J. Neurosci. (1985) [Pubmed]
  13. Distributions of synaptic vesicle proteins and GAD65 in deprived and nondeprived ocular dominance columns in layer IV of kitten primary visual cortex are unaffected by monocular deprivation. Silver, M.A., Stryker, M.P. J. Comp. Neurol. (2000) [Pubmed]
  14. The distribution of glutamic acid decarboxylase immunoreactivity in the diencephalon of the opossum and rabbit. Penny, G.R., Conley, M., Schmechel, D.E., Diamond, I.T. J. Comp. Neurol. (1984) [Pubmed]
  15. Immunohistochemical demonstration of differential substance P-, met-enkephalin-, and glutamic-acid-decarboxylase-containing cell body and axon distributions in the corpus striatum of the cat. Beckstead, R.M., Kersey, K.S. J. Comp. Neurol. (1985) [Pubmed]
  16. Physiological properties of late inspiratory neurons and their possible involvement in inspiratory off-switching in cats. Haji, A., Okazaki, M., Yamazaki, H., Takeda, R. J. Neurophysiol. (2002) [Pubmed]
  17. Distribution of cholinergic, GABAergic and serotonergic neurons in the medial medullary reticular formation and their projections studied by cytotoxic lesions in the cat. Holmes, C.J., Mainville, L.S., Jones, B.E. Neuroscience (1994) [Pubmed]
  18. Networks of inhibitory and excitatory commissural interneurons mediating crossed reticulospinal actions. Bannatyne, B.A., Edgley, S.A., Hammar, I., Jankowska, E., Maxwell, D.J. Eur. J. Neurosci. (2003) [Pubmed]
  19. Localization of L-glutamic acid decarboxylase mRNA in cat retinal horizontal cells by in situ hybridization. Sarthy, P.V., Fu, M. J. Comp. Neurol. (1989) [Pubmed]
  20. Distribution of immunoreactivity for the beta 2 and beta 3 subunits of the GABAA receptor in the mammalian spinal cord. Alvarez, F.J., Taylor-Blake, B., Fyffe, R.E., De Blas, A.L., Light, A.R. J. Comp. Neurol. (1996) [Pubmed]
  21. Immunocytochemical localization of glutamic acid decarboxylase (GAD) and glutamine synthetase (GS) in the area postrema of the cat. Light and electron microscopy. D'Amelio, F.E., Mehler, W.R., Gibbs, M.A., Eng, L.F., Wu, J.Y. Brain Res. (1987) [Pubmed]
  22. Expression of two forms of glutamic acid decarboxylase (GAD67 and GAD65) during postnatal development of the cat visual cortex. Guo, Y., Kaplan, I.V., Cooper, N.G., Mower, G.D. Brain Res. Dev. Brain Res. (1997) [Pubmed]
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