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Yano, T. et al.

Yano, Uchida, Yuasa, Murakami, Hagiwara, Ichikawa,

The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice.

In this study, we investigated the effect of vitamin E on the activation of the K-ras oncogene with a 61st codon A-->T mutation at an early stage of urethane-induced lung carcinogenesis in mice. Thirty days after urethane injection, the K-ras mutation was detected in 64% of lung samples tested by mutant-allele-specific amplification. The consumption of a supplemented diet with about 20-times more vitamin E than the control diet, only during the promotion phase or during both the initiation and promotion phases of lung carcinogenesis, reduced the frequency of the mutation to 36 and 18%, respectively. Also, vitamin E suppressed the level of proliferating cell nuclear antigen as a marker of cell proliferation in the lungs of mice treated with urethane. These results support the notion that vitamin E is a useful chemopreventive agent against lung cancer.[1]

References

The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice. Yano, T., Uchida, M., Yuasa, M., Murakami, A., Hagiwara, K., Ichikawa, T. Eur. J. Pharmacol. (1997) [Pubmed]

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