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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Evidence for an HLA-linked resistance gene in Buerger's disease.

The incidence of Thromboangiitis Obliterans in brothers and the high prevalence in some ethnic groups have led us to investigate the histocompatibility HLA-A, B and DR antigens of 46 Buerger's disease patients. The main result indicates a marked decreased freqeuncy of the B12 antigen: 2.2% vs 28% in controls. Our study suggests that Buerger's disease is, on the basis of HLA antigens, a distinct immunogenetic entity and not a particular form of arteriosclerosis. Moreover, this disorder may represent a clue to the existence of resistance genes linked to HLA.[1]


  1. Evidence for an HLA-linked resistance gene in Buerger's disease. de Moerloose, P., Jeannet, M., Mirimanoff, P., Bouvier, C.A. Tissue Antigens (1979) [Pubmed]
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