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Disease relevance of Immunogenetics


Psychiatry related information on Immunogenetics


High impact information on Immunogenetics

  • The results indicate that rheumatoid arthritis in whites is associated with genes of the HLA-D region and that immunogenetic factors linked to HLA have a role in its pathogenesis [7].
  • Immunogenetics. Viruses, cancer and the MHC [8].
  • Mutant mouse strains are important tools for immunogenetic studies of the regulation, structure and function of major histocompatibility (H-2) antigens1-3 [9].
  • The data indicate that immunogenetic factors are relevant to the development of both RA and SLE, but that these are distinct for each disease [10].
  • It remains to be determined whether killing and suppression are functionally interrelated properties of a single Ly23 subclass, or whether the Ly23 population comprises two subclasses whose surface phenotypes are not yet distinguishable by immunogenetic criteria [11].

Chemical compound and disease context of Immunogenetics


Biological context of Immunogenetics


Anatomical context of Immunogenetics

  • We have utilized a clonal approach to investigate functional and immunogenetic characteristics of T cells responsive to the miHA H-1 [22].
  • This analysis was performed by functional and immunogenetic characterization of a large number of clones derived from short-term mixed leukocyte culture (MLC) populations generated against the miHA, H-1 [23].
  • To determine the immunogenetic characteristics of patients with immune-mediated subepithelial blistering diseases of mucous membranes, we performed HLA-typing for the class II MHC gene DQB1*0301 allele using a direct method [24].
  • The features of these two cases extend the known clinical and pathological spectrum of this disease and, through identifying a common immunogenetic background, provide a possible link between the previous associations of this disorder and autoimmune thyroid disease and IDDM [25].
  • OBSERVATIONS: The interacting immunogenetic and environmental factors, especially UV irradiation, result in the inability of the patients' immune system to respond to epidermodysplasia verruciformis-specific human papillomaviruses [26].

Associations of Immunogenetics with chemical compounds


Gene context of Immunogenetics


Analytical, diagnostic and therapeutic context of Immunogenetics


  1. Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis. Arnett, F.C., Reveille, J.D., Goldstein, R., Pollard, K.M., Leaird, K., Smith, E.A., Leroy, E.C., Fritzler, M.J. Arthritis Rheum. (1996) [Pubmed]
  2. Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Starkebaum, G., Loughran, T.P., Gaur, L.K., Davis, P., Nepom, B.S. Arthritis Rheum. (1997) [Pubmed]
  3. Clinical and immunogenetic correlates of abacavir hypersensitivity. Phillips, E.J., Wong, G.A., Kaul, R., Shahabi, K., Nolan, D.A., Knowles, S.R., Martin, A.M., Mallal, S.A., Shear, N.H. AIDS (2005) [Pubmed]
  4. HLA extended haplotypes in steroid-sensitive nephrotic syndrome of childhood. Lagueruela, C.C., Buettner, T.L., Cole, B.R., Kissane, J.M., Robson, A.M. Kidney Int. (1990) [Pubmed]
  5. Relationship between ultraviolet radiation-induced immunosuppression and carcinogenesis. Streilein, J.W., Taylor, J.R., Vincek, V., Kurimoto, I., Richardson, J., Tie, C., Medema, J.P., Golomb, C. J. Invest. Dermatol. (1994) [Pubmed]
  6. Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia: a study of two unrelated Italian cases. Manni, R., Martinetti, M., Ratti, M.T., Tartara, A. Acta neurologica Scandinavica. (1993) [Pubmed]
  7. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. Stastny, P. N. Engl. J. Med. (1978) [Pubmed]
  8. Immunogenetics. Viruses, cancer and the MHC. Klitz, W. Nature (1992) [Pubmed]
  9. Evidence for mutation in an I-A gene. Hansen, T.H., Melvold, R.W., Arn, J.S., Sachs, D.H. Nature (1980) [Pubmed]
  10. Disease associations of the Ia-like human alloantigens. Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus. Gibofsky, A., Winchester, R.J., Patarroyo, M., Fotino, M., Kunkel, H.G. J. Exp. Med. (1978) [Pubmed]
  11. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. Cantor, H., Shen, F.W., Boyse, E.A. J. Exp. Med. (1976) [Pubmed]
  12. The effects of lithium therapy on thyroid and thyrotropin-releasing hormone. Lazarus, J.H. Thyroid (1998) [Pubmed]
  13. Clinical, serologic and immunogenetic studies in patients with chronic cutaneous (discoid) lupus erythematosus who have verrucous and/or hypertrophic skin lesions. Spann, C.R., Callen, J.P., Klein, J.B., Kulick, K.B. J. Rheumatol. (1988) [Pubmed]
  14. Fast food arthritis--a clinico-pathologic study of post-Salmonella reactive arthritis. Samuel, M.P., Zwillich, S.H., Thomson, G.T., Alfa, M., Orr, K.B., Brittain, D.C., Miller, J.R., Phillips, P.E. J. Rheumatol. (1995) [Pubmed]
  15. Dapsone is an effective therapy for the skin lesions of subacute cutaneous lupus erythematosus and urticarial vasculitis in a patient with C2 deficiency. Holtman, J.H., Neustadt, D.H., Klein, J., Callen, J.P. J. Rheumatol. (1990) [Pubmed]
  16. Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A. Cebeci, I., Kantarci, A., Firatli, E., Aygün, S., Tanyeri, H., Aydin, A.E., Carin, M., Güç, U., Tuncer, O. Journal of clinical periodontology. (1996) [Pubmed]
  17. Evidence for the association of unexplained pulmonary hypertension in children with the major histocompatibility complex. Barst, R.J., Flaster, E.R., Menon, A., Fotino, M., Morse, J.H. Circulation (1992) [Pubmed]
  18. The human COL11A2 gene structure indicates that the gene has not evolved with the genes for the major fibrillar collagens. Vuristo, M.M., Pihlajamaa, T., Vandenberg, P., Prockop, D.J., Ala-Kokko, L. J. Biol. Chem. (1995) [Pubmed]
  19. Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease. Badenhoop, K., Walfish, P.G., Rau, H., Fischer, S., Nicolay, A., Bogner, U., Schleusener, H., Usadel, K.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  20. Investigations of red cell glyoxalase in recombinant families. Pretorius, A.M., Scholz, S., Kuntz, B., Albert, E.D. Eur. J. Immunol. (1976) [Pubmed]
  21. Sequences of the mouse F protein alleles and identification of a T cell epitope. Schofield, J.P., Vijayakumar, R.K., Oliveira, D.B. Eur. J. Immunol. (1991) [Pubmed]
  22. Responses against single minor histocompatibility antigens. II. Analysis of cloned helper T cells. Roopenian, D.C., Orosz, C.G., Bach, F.H. J. Immunol. (1984) [Pubmed]
  23. Response against single minor histocompatibility antigens. I. Functional and immunogenetic analysis of cloned cytolytic T cells. Roopenian, D.C., Widmer, M.B., Orosz, C.G., Bach, F.H. J. Immunol. (1983) [Pubmed]
  24. Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid. Chan, L.S., Hammerberg, C., Cooper, K.D. J. Invest. Dermatol. (1997) [Pubmed]
  25. Lymphocytic hypophysitis. The clinical spectrum of the disorder and evidence for an autoimmune pathogenesis. Pestell, R.G., Best, J.D., Alford, F.P. Clin. Endocrinol. (Oxf) (1990) [Pubmed]
  26. Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin. Majewski, S., Jabłońska, S. Archives of dermatology. (1995) [Pubmed]
  27. Tumor necrosis factor: immunogenetics and disease. Hauser, S.L. Ann. Neurol. (1995) [Pubmed]
  28. HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease. Lombardi, G., Germain, C., Uren, J., Fiorillo, M.T., du Bois, R.M., Jones-Williams, W., Saltini, C., Sorrentino, R., Lechler, R. J. Immunol. (2001) [Pubmed]
  29. Immunogenetic analysis of the immune response to pneumococcal polysaccharide. Baxendale, H.E., Davis, Z., White, H.N., Spellerberg, M.B., Stevenson, F.K., Goldblatt, D. Eur. J. Immunol. (2000) [Pubmed]
  30. Methotrexate treatment in patients with adult onset Still's disease--retrospective study of 13 Japanese cases. Fujii, T., Akizuki, M., Kameda, H., Matsumura, M., Hirakata, M., Yoshida, T., Shinozawa, T., Mimori, T. Ann. Rheum. Dis. (1997) [Pubmed]
  31. Entrez into the immunogenetics of superficial bladder cancer response to bacillus Calmette-Guerin. O'Donnell, M. J. Urol. (2006) [Pubmed]
  32. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Orchard, T.R., Chua, C.N., Ahmad, T., Cheng, H., Welsh, K.I., Jewell, D.P. Gastroenterology (2002) [Pubmed]
  33. Immunogenetics of BCG-induced anergy in mice: control by genes linked to the Igh complex. Schrier, D.J., Sternick, J.L., Allen, E.M., Moore, V.L. J. Immunol. (1982) [Pubmed]
  34. Simultaneous analysis of interleukin-10 gene microsatellites and single-nucleotide polymorphisms in parallel with tumour necrosis factor and interferon-gamma short tandem repeats by fluorescence-based polymerase chain reaction. Kube, D., Mörmann, M., Tomiuk, J., Rieth, H., Hua, T.D., Kremsner, P.G., Vockerodt, M. Genes Immun. (2003) [Pubmed]
  35. PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Gomez, L.M., Anaya, J.M., Gonzalez, C.I., Pineda-Tamayo, R., Otero, W., Arango, A., Martín, J. Genes Immun. (2005) [Pubmed]
  36. Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. Vehe, R.K., Nepom, G.T., Wilske, K.R., Stage, D., Begovich, A.B., Nepom, B.S. J. Rheumatol. (1994) [Pubmed]
  37. Non-HLA immunogenetics in hematopoietic stem cell transplantation. Dickinson, A.M., Charron, D. Curr. Opin. Immunol. (2005) [Pubmed]
  38. Promiscuous T cells selected by Escherichia coli: OGDC-E2 in primary biliary cirrhosis. Tanimoto, H., Shimoda, S., Nakamura, M., Ishibashi, H., Kawano, A., Kamihira, T., Matsushita, S., Gershwin, M.E., Harada, M. J. Autoimmun. (2003) [Pubmed]
  39. The development of rheumatoid arthritis after recombinant hepatitis B vaccination. Pope, J.E., Stevens, A., Howson, W., Bell, D.A. J. Rheumatol. (1998) [Pubmed]
  40. Low prevalence of immunogenetic markers of IDDM in adult Koreans with diabetes detected on OGTT. Park, Y., Lee, H., Koh, C.S., Min, H., Zimmet, P.Z., Rowley, M.J., Mackay, I.R., Trucco, M., Dorman, J.S. Diabetes Res. Clin. Pract. (1996) [Pubmed]
  41. Cis-trans complementation of DQA1-DQB1 genes are modulated by DQ alleles: an immunogenetics analysis of DQ association with the down-regulatory function of CD8 cells in trichosanthin-induced immunosuppression. Chou, K.Y., Fu, S.L., Li, N.L., Huang, L.D., Wang, F.Q., Lu, P.H., Fan, L.A. Eur. J. Immunogenet. (1999) [Pubmed]
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