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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.

Murine CD1 has been implicated in the development and function of an unusual subset of T cells, termed natural T ( NT) cells, that coexpress the T cell receptor (TCR) and the natural killer cell receptor NK1. 1. Activated NT cells promptly produce large amounts of IL-4, suggesting that these cells can influence the differentiation of CD4+ effector T cell subsets. We have generated mice that carry a mutant CD1d1 gene. NT cell numbers in the thymus, spleen, and liver of these mice were dramatically reduced. Activated splenocytes from mutant mice did not produce IL-4, whereas similarly treated wild-type splenocytes secreted large amounts of this cytokine. These results demonstrate a critical role for CD1 in the positive selection and function of NT cells.[1]

References

  1. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Mendiratta, S.K., Martin, W.D., Hong, S., Boesteanu, A., Joyce, S., Van Kaer, L. Immunity (1997) [Pubmed]
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