- Nuclear accumulation of HMG2 protein is mediated by basic regions interspaced with a long DNA-binding sequence, and retention within the nucleus requires the acidic carboxyl terminus. Shirakawa, H., Tanigawa, T., Sugiyama, S., Kobayashi, M., Terashima, T., Yoshida, K., Arai, T., Yoshida, M. Biochemistry (1997)