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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antioxidant activity of reduced menadione in solvent solution and in model membranes.

The antioxidant activity of reduced menadione was investigated and compared with that of alpha-tocopherol both in solvent solution and in large unilamellar vesicles by using azocompounds as free radical generators. The results show that: i) reduced menadione behaves as a chain-breaking antioxidant; ii) its inhibition rate constant is similar to that of alpha-tocopherol in homogeneous solution, whereas it is 4 times larger in egg yolk lecithin vesicles; iii) the stoichiometric factor is found lower than 1 in both systems, since a substantial portion of menadiol is consumed by autoxidation and does not contribute to radical trapping; iv) when both alpha-tocopherol and menadiol are present in vesicles, reduced menadione can spare alpha-tocopherol. Data presented here suggest that the reduced form of vitamin K may protect, when present, cellular membranes from free radical damage.[1]


  1. Antioxidant activity of reduced menadione in solvent solution and in model membranes. Fiorentini, D., Cipollone, M., Galli, M.C., Landi, L. Free Radic. Res. (1997) [Pubmed]
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