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Chemical Compound Review

Menadiol     2-methylnaphthalene-1,4-diol

Synonyms: protrombrovit, Vitamin K3H2, Menadiol (BAN), SureCN297164, CHEBI:6746, ...
 
 
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Disease relevance of Menadiol

 

High impact information on Menadiol

 

Chemical compound and disease context of Menadiol

 

Biological context of Menadiol

 

Anatomical context of Menadiol

 

Associations of Menadiol with other chemical compounds

  • These results show that menadione exerts an antioxidant effect through participation of microsomal DT-diaphorase by generating menadiol with a radical scavenging ability, while menadiol also has a prooxidant property [12].
  • The antioxidant activity of reduced menadione was investigated and compared with that of alpha-tocopherol both in solvent solution and in large unilamellar vesicles by using azocompounds as free radical generators [11].
  • An in vitro quinol dehydrogenase assay was developed to show that both NapG and NapH are essential for rapid electron transfer from menadiol to the terminal NapAB complex [13].
 

Analytical, diagnostic and therapeutic context of Menadiol

  • The synthesis and purification of menadiol diphosphate are described, and it was shown to be sufficiently stable for qualitative and semiquantitative histochemistry, as well as for the immunohistochemistry of enzymes and cytoskeletal proteins with nonspecific alkaline phosphatase as the enzyme label [10].

References

  1. Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study. Zhao, Z., Rothery, R.A., Weiner, J.H. Biochemistry (2003) [Pubmed]
  2. Phytomenadione or menadiol in the management of an elevated international normalized ratio (prothrombin time). Green, B., Cairns, S., Harvey, R., Pettit, M. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  3. Characterization of the norB gene, encoding nitric oxide reductase, in the nondenitrifying cyanobacterium Synechocystis sp. strain PCC6803. Büsch, A., Friedrich, B., Cramm, R. Appl. Environ. Microbiol. (2002) [Pubmed]
  4. Selective enhancement by menadiol of in vitro drug activity in human lymphatic neoplasms. Su, Y.Z., Duarte, T.E., Dill, P.L., Weisenthal, L.M. Cancer treatment reports. (1987) [Pubmed]
  5. Detection of superoxide generated by endothelial cells. Rosen, G.M., Freeman, B.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  6. Characterization of the Desulfovibrio desulfuricans ATCC 27774 DsrMKJOP complex--a membrane-bound redox complex involved in the sulfate respiratory pathway. Pires, R.H., Venceslau, S.S., Morais, F., Teixeira, M., Xavier, A.V., Pereira, I.A. Biochemistry (2006) [Pubmed]
  7. Purification and characterization of the single-component nitric oxide reductase from Ralstonia eutropha H16. Cramm, R., Pohlmann, A., Friedrich, B. FEBS Lett. (1999) [Pubmed]
  8. The role of lipid peroxidation in menadione-mediated toxicity in cardiomyocytes. Tzeng, W.F., Lee, J.L., Chiou, T.J. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  9. Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli. Hayashi, M., Hasegawa, K., Oguni, Y., Unemoto, T. Biochim. Biophys. Acta (1990) [Pubmed]
  10. Menadiol diphosphate, a new substrate for non-specific alkaline phosphatase in histochemistry and immunohistochemistry. Dikow, A., Gossrau, R., Frank, H.G. Histochemistry (1990) [Pubmed]
  11. Antioxidant activity of reduced menadione in solvent solution and in model membranes. Fiorentini, D., Cipollone, M., Galli, M.C., Landi, L. Free Radic. Res. (1997) [Pubmed]
  12. Enzymatic and molecular aspects of the antioxidant effect of menadione in hepatic microsomes. Tampo, Y., Yonaha, M. Arch. Biochem. Biophys. (1996) [Pubmed]
  13. NapGH components of the periplasmic nitrate reductase of Escherichia coli K-12: location, topology and physiological roles in quinol oxidation and redox balancing. Brondijk, T.H., Nilavongse, A., Filenko, N., Richardson, D.J., Cole, J.A. Biochem. J. (2004) [Pubmed]
 
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