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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A seven days course of eflornithine for relapsing Trypanosoma brucei gambiense sleeping sickness.

Forty-seven patients with a relapse following a first treatment of Trypanosoma brucei gambiense trypanosomiasis were treated with a 7 d course of intravenous eflornithine (100 mg/kg every 6 h) and followed for 2 years. Four patients died after treatment, 2 of them possibly due to trypanosomiasis. One patient was completely lost to follow-up, 36 were followed for at least one year, and 25 have completed the 2 years' follow-up. Only one patient, a 5 years old child, subsequently relapsed. Considering this child and 2 of the fatalities as treatment failures, the rate of failure was 6.5%. A 7 d course of intravenous eflornithine is an adequate treatment for cases of Gambian trypanosomiasis relapsing after treatment with another drug.[1]

References

  1. A seven days course of eflornithine for relapsing Trypanosoma brucei gambiense sleeping sickness. Khonde, N., Pépin, J., Mpia, B. Trans. R. Soc. Trop. Med. Hyg. (1997) [Pubmed]
 
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