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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Trypanosomiasis


High impact information on Trypanosomiasis


Chemical compound and disease context of Trypanosomiasis


Biological context of Trypanosomiasis


Anatomical context of Trypanosomiasis


Gene context of Trypanosomiasis

  • Mapping in the AILs also resolved the Tir3 locus into three trypanosomiasis resistance QTLs, revealing a degree of complexity not evident in extensive studies at the F(2) level [21].
  • These results are important for future cytokine and trypanosomiasis pathology studies, because the interplay between TNF and the soluble receptors it sheds has not been considered in either human clinical sleeping sickness studies or in veterinary trypanosomiasis research [22].
  • Drug-induced modulation of IL-2 production in experimental murine trypanosomiasis [23].
  • Thus, we propose a role for OpdB in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of ANF in mammals infected with T. evansi [24].
  • Molecular identity and location of invariant antigens on Trypanosoma brucei rhodesiense defined with monoclonal antibodies reactive with sera from trypanosomiasis patients [25].

Analytical, diagnostic and therapeutic context of Trypanosomiasis


  1. Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III. Mitsuya, H., Popovic, M., Yarchoan, R., Matsushita, S., Gallo, R.C., Broder, S. Science (1984) [Pubmed]
  2. Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin. Betsholtz, C., Johnsson, A., Heldin, C.H., Westermark, B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Antiproliferative effects of suramin on lymphoid cells. Spigelman, Z., Dowers, A., Kennedy, S., DiSorbo, D., O'Brien, M., Barr, R., McCaffrey, R. Cancer Res. (1987) [Pubmed]
  4. Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme. Ariza, A., Vickers, T.J., Greig, N., Armour, K.A., Dixon, M.J., Eggleston, I.M., Fairlamb, A.H., Bond, C.S. Mol. Microbiol. (2006) [Pubmed]
  5. Investigations of the metabolites of the trypanocidal drug melarsoprol. Keiser, J., Ericsson, O., Burri, C. Clin. Pharmacol. Ther. (2000) [Pubmed]
  6. Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis. Arrick, B.A., Griffith, O.W., Cerami, A. J. Exp. Med. (1981) [Pubmed]
  7. Topical melarsoprol for trypanosomiasis. Jennings, F.W., Atouguia, J.M., Murray, M. Lancet (1993) [Pubmed]
  8. Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness. Pepin, J., Milord, F., Guern, C., Mpia, B., Ethier, L., Mansinsa, D. Lancet (1989) [Pubmed]
  9. Salicylhydroxamic-acid/glycerol in experimental trypanosomiasis. Evans, D.A., Brightman, C.J., Holland, M.F. Lancet (1977) [Pubmed]
  10. Free fatty acids, lysophosphatidylcholine, and pathogenesis of trypanosomiasis. Roberts, C.J., Clarleson, M.J. Lancet (1977) [Pubmed]
  11. Difluoromethylornithine, an effective new treatment of Gambian trypanosomiasis. Results in five patients. Taelman, H., Schechter, P.J., Marcelis, L., Sonnet, J., Kazyumba, G., Dasnoy, J., Haegele, K.D., Sjoerdsma, A., Wery, M. Am. J. Med. (1987) [Pubmed]
  12. Characterization of a novel DNA minor-groove complex. Nguyen, B., Hamelberg, D., Bailly, C., Colson, P., Stanek, J., Brun, R., Neidle, S., Wilson, W.D. Biophys. J. (2004) [Pubmed]
  13. Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. Walzer, P.D., Kim, C.K., Foy, J., Linke, M.J., Cushion, M.T. Antimicrob. Agents Chemother. (1988) [Pubmed]
  14. Field evaluation of the prophylactic effect of an isometamidium sustained-release device against trypanosomiasis in cattle. Diarra, B., Diall, O., Geerts, S., Kageruka, P., Lemmouchi, Y., Schacht, E., Eisler, M.C., Holmes, P. Antimicrob. Agents Chemother. (1998) [Pubmed]
  15. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs. Chan, C., Yin, H., Garforth, J., McKie, J.H., Jaouhari, R., Speers, P., Douglas, K.T., Rock, P.J., Yardley, V., Croft, S.L., Fairlamb, A.H. J. Med. Chem. (1998) [Pubmed]
  16. Variations in packed red cell volume and trypanosome prevalence and relationships with reproductive traits in east African Zebu cows exposed to drug-resistant trypanosomes. Rowlands, G.J., Mulatu, W., Nagda, S.M., d'Ieteren, G.D. Acta Trop. (1995) [Pubmed]
  17. Assessment of central nervous system involvement in gambiense trypanosomiasis: value of the cerebro-spinal white cell count. Miezan, T.W., Meda, H.A., Doua, F., Yapo, F.B., Baltz, T. Trop. Med. Int. Health (1998) [Pubmed]
  18. Impact of the development of agricultural land on the transmission of sleeping sickness in Daloa, Côte d'Ivoire. Fournet, F., Traore, S., Prost, A., Cadot, E., Hervouët, J.P. Ann. Trop. Med. Parasitol. (2000) [Pubmed]
  19. Plasma luteinizing hormone levels in response to gonadotropin-releasing hormone agonist and clonidine in Trypanosoma congolense-infected female goats. Ng'wena, A.G., Patel, N.B., Wango, E.O. Brain Res. Bull. (1997) [Pubmed]
  20. Histamine levels in tissues of Trypanosoma cruzi-infected mice. Pires, J.G., Milanez, M.C., Pereira, F.E. Agents Actions Suppl. (1992) [Pubmed]
  21. Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Iraqi, F., Clapcott, S.J., Kumari, P., Haley, C.S., Kemp, S.J., Teale, A.J. Mamm. Genome (2000) [Pubmed]
  22. P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. Magez, S., Truyens, C., Merimi, M., Radwanska, M., Stijlemans, B., Brouckaert, P., Brombacher, F., Pays, E., De Baetselier, P. J. Infect. Dis. (2004) [Pubmed]
  23. Drug-induced modulation of IL-2 production in experimental murine trypanosomiasis. Calabresi, A., Perito, S., Romani, L., Bistoni, F. Int. J. Immunopharmacol. (1992) [Pubmed]
  24. Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts. Morty, R.E., Pellé, R., Vadász, I., Uzcanga, G.L., Seeger, W., Bubis, J. J. Biol. Chem. (2005) [Pubmed]
  25. Molecular identity and location of invariant antigens on Trypanosoma brucei rhodesiense defined with monoclonal antibodies reactive with sera from trypanosomiasis patients. Burgess, D.E., Jerrells, T. Infect. Immun. (1985) [Pubmed]
  26. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Troeberg, L., Chen, X., Flaherty, T.M., Morty, R.E., Cheng, M., Hua, H., Springer, C., McKerrow, J.H., Kenyon, G.L., Lonsdale-Eccles, J.D., Coetzer, T.H., Cohen, F.E. Mol. Med. (2000) [Pubmed]
  27. Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines. Bacchi, C.J., Nathan, H.C., Hutner, S.H., McCann, P.P., Sjoerdsma, A. Biochem. Pharmacol. (1982) [Pubmed]
  28. Teratogenic effects of suramin on the chick embryo. Männer, J., Seidl, W., Heinicke, F., Hesse, H. Anat. Embryol. (2003) [Pubmed]
  29. A seven days course of eflornithine for relapsing Trypanosoma brucei gambiense sleeping sickness. Khonde, N., Pépin, J., Mpia, B. Trans. R. Soc. Trop. Med. Hyg. (1997) [Pubmed]
  30. Serodiagnosis of African sleeping sickness in vervet monkeys by detection of parasite antigens. Liu, M.K., Pearson, T.W., Sayer, P.D., Gould, S.S., Waitumbi, J.N., Njogu, A.R. Acta Trop. (1988) [Pubmed]
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