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Radioimmunoassay of human beta-lipotropin in unextracted plasma.

A sensitive and specific radioimmunoassay for human beta-lipotropin (betah-LPH) in unextracted plasma was developed using pur betah-LPH as tracer and standard and an antiserum not cross-reacting with human beta-MSH and hACTH. In healthy volunteers plasma betah-LPH ranged from less than 20 to 150 pg/ml at 8:00 a.m. and rose after metyrapone administration. betah-LPH was very low in panhypopituitarism, normal in most patients with untreated Cushing's disease, elevated in acromegaly and extremely high in Nelson's syndrome.[1]


  1. Radioimmunoassay of human beta-lipotropin in unextracted plasma. Wiedemann, E., Saito, T., Linfoot, J.A., Li, C.H. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
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