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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metabolism of catechol estrogen by human erythrocytes.

In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC's was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.[1]


  1. Metabolism of catechol estrogen by human erythrocytes. Bates, G.W., Edman, C.D., Porter, J.C., MacDonald, P.C. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
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