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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera.

The v-jun oncogene encodes a nuclear DNA binding protein that functions as a transcription factor and is part of the activator protein 1 complex. Oncogenic transformation by v-jun is thought to be mediated by the aberrant expression of specific target genes. To identify such Jun-regulated genes and to explore the mechanisms by which Jun affects their expression, we have fused the full-length v-Jun and an amino-terminally truncated form of v-Jun to the hormone-binding domain of the human estrogen receptor. The two chimeric proteins function as ligand-inducible transactivators. Expression of the fusion proteins in chicken embryo fibroblasts causes estrogen-dependent transformation.[1]


  1. Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera. Kruse, U., Iacovoni, J.S., Goller, M.E., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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