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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Driessen, C.A. et al.

Driessen, Winkens, Kuhlmann, Janssen, van Vugt, Deutman, Janssen,

Cloning and structural analysis of the murine GCN5L1 gene.

We recently cloned the murine 11-cis retinol dehydrogenase gene. A second gene, the murine GCN5L1 gene, was found to be situated upstream of the murine 11-cis retinol dehydrogenase gene. We have isolated and sequenced the complete coding sequence of the murine GCN5L1 gene. The distance between the 3'-end of the murine GCN5L1 gene and the 5'-end of the 11-cis retinol dehydrogenase gene is only 776 nt. The murine GCNSL1 gene consists of four exons encompassing approximately 3.5 kb of genomic DNA. Intron/exon splice sites conform to the GT/AG rule. The open reading frame consists of 375 nucleotides encoding a 14 kDa protein. The murine GCN5L1, like the human GCN5L1 protein, displays weak homology (27%) to yeast GCN5. The distance between the murine, human and bovine GCN5L1 and 11-cis retinol dehydrogenase genes appeared to be conserved.[1]

References

Cloning and structural analysis of the murine GCN5L1 gene. Driessen, C.A., Winkens, H.J., Kuhlmann, L.D., Janssen, B.P., van Vugt, A.H., Deutman, A.F., Janssen, J.J. Gene (1997) [Pubmed]

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