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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Periapical repair and apical closure of a pulpless tooth using calcium hydroxide.

A case with a wide-open apex and a large cystlike periapical lesion in an adult is presented. The lesion formed as a result of necrosis from trauma to a maxillary central incisor 12 years ago. After nonsurgical endodontic treatment with calcium hydroxide paste and a calcium hydroxide-containing root canal sealer, apical closure and significant healing of the periapical lesion within 15 months were observed. This report suggests that even large periapical lesions (likely cystic) could respond favorably to nonsurgical treatment.[1]


  1. Periapical repair and apical closure of a pulpless tooth using calcium hydroxide. Calişkan, M.K., Türkün, M. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1997) [Pubmed]
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