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Chemical Compound Review

AC1MMT9N     calcium hydroxide

Synonyms: AC1O1JFB, FT-0623399, I14-93317
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Disease relevance of calcium hydroxide


Psychiatry related information on calcium hydroxide


High impact information on calcium hydroxide


Chemical compound and disease context of calcium hydroxide


Biological context of calcium hydroxide


Anatomical context of calcium hydroxide

  • We observed its immunohistochemical localization during dentin bridge formation in human teeth, after pulp was capped with calcium hydroxide [Ca(OH)2] [16].
  • The results from this study showed a variety of pulpal responses to various calcium hydroxide materials when placed directly on the dental pulp [21].
  • Human pulp fibroblast but not human submandibular gland cells showed a high resistance against calcium hydroxide [10].
  • These characteristics may account for why E. faecalis is frequently isolated from acidic caries lesions and from persistently infected root canals where calcium hydroxide medication is ineffective [22].
  • The pulps of 78 sound premolars were capped with SBAS after 37% phosphoric acid etching (Group I) or 10% phosphoric acid etching (Group II) and CH (Group III-control) [23].

Associations of calcium hydroxide with other chemical compounds


Gene context of calcium hydroxide


Analytical, diagnostic and therapeutic context of calcium hydroxide


  1. A new technique for screening chemical toxicity to the pulp from dental restorative materials and procedures. Hume, W.R. J. Dent. Res. (1985) [Pubmed]
  2. Carcinogenicity examination of betel quid. II. Effect of vitamin A deficiency on rats fed semipurified diet containing betel nut and calcium hydroxide. Tanaka, T., Mori, H., Fujii, M., Takahashi, M., Hirono, I. Nutrition and cancer. (1983) [Pubmed]
  3. Bacterial reduction and persistence after endodontic treatment procedures. Sakamoto, M., Siqueira, J.F., Rôças, I.N., Benno, Y. Oral Microbiol. Immunol. (2007) [Pubmed]
  4. Viruses in sewage: effect of phosphate removal with calcium hydroxide (lime). Sattar, S.A., Ramia, S. Can. J. Microbiol. (1978) [Pubmed]
  5. Weight loss of four calcium hydroxide-based materials following a phosphoric acid etching and washing cycle. Burke, F.J., Watts, D.C. Journal of dentistry. (1986) [Pubmed]
  6. Betel quid and reaction time. Stricherz, M.E., Pratt, P. Pharmacol. Biochem. Behav. (1976) [Pubmed]
  7. Dentin matrix protein 1 induces cytodifferentiation of dental pulp stem cells into odontoblasts. Almushayt, A., Narayanan, K., Zaki, A.E., George, A. Gene Ther. (2006) [Pubmed]
  8. Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro. Nair, U.J., Friesen, M., Richard, I., MacLennan, R., Thomas, S., Bartsch, H. Carcinogenesis (1990) [Pubmed]
  9. Effectiveness of 4 pulpotomy techniques--randomized controlled trial. Huth, K.C., Paschos, E., Hajek-Al-Khatar, N., Hollweck, R., Crispin, A., Hickel, R., Folwaczny, M. J. Dent. Res. (2005) [Pubmed]
  10. Interaction between 2-ethoxybenzoic acid (EBA) and eugenol, and related changes in cytotoxicity. Fujisawa, S., Atsumi, T., Satoh, K., Sakagami, H. J. Dent. Res. (2003) [Pubmed]
  11. Prevention of hydrolysable tannin toxicity in goats fed Clidemia hirta by calcium hydroxide supplementation. Murdiati, T.B., McSweeney, C.S., Campbell, R.S., Stoltz, D.S. Journal of applied toxicology : JAT. (1990) [Pubmed]
  12. Unextracted cottonseed in diets for monogastric animals. I. The effect of ferrous sulfate and calcium hydroxide in reducing gossypol toxicity. Clawson, A.J., Maner, J.H., Gomez, G., Mejia, O., Flores, Z., Buitrago, J. J. Anim. Sci. (1975) [Pubmed]
  13. Antimicrobial efficacy of chlorhexidine and two calcium hydroxide formulations against Enterococcus faecalis. Schäfer, E., Bössmann, K. Journal of endodontics. (2005) [Pubmed]
  14. The effect of sodium hypochlorite application on the success of calcium hydroxide pulpotomy in primary teeth. Tunç, E.S., Saroğlu, I., Sari, S., Günhan, O. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2006) [Pubmed]
  15. The relationship of intracanal medicaments to postoperative pain in endodontics. Ehrmann, E.H., Messer, H.H., Adams, G.G. International endodontic journal. (2003) [Pubmed]
  16. Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide. Yoshiba, K., Yoshiba, N., Nakamura, H., Iwaku, M., Ozawa, H. J. Dent. Res. (1996) [Pubmed]
  17. Hard tissue barrier formation in pulpotomized monkey teeth capped with cyanoacrylate or calcium hydroxide for 10 and 60 minutes. Cvek, M., Granath, L., Cleaton-Jones, P., Austin, J. J. Dent. Res. (1987) [Pubmed]
  18. Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. Schröder, U. J. Dent. Res. (1985) [Pubmed]
  19. Immunohistochemical study of dental pulp applied with 4-META/MMA-TBB adhesive resin after pulpotomy. Nakamura, M., Inoue, T., Shimono, M. J. Biomed. Mater. Res. (2000) [Pubmed]
  20. Hydrolysis of sucrose octa-acetate: qualitative differences in taster and demistaster avoidance phenotypes. Capeless, C.G., Boughter, J.D., Whitney, G. Chem. Senses (1994) [Pubmed]
  21. Histological considerations of direct pulp capping agents. Heys, D.R., Cox, C.F., Heys, R.J., Avery, J.K. J. Dent. Res. (1981) [Pubmed]
  22. Resistance to acidic and alkaline environments in the endodontic pathogen Enterococcus faecalis. Nakajo, K., Komori, R., Ishikawa, S., Ueno, T., Suzuki, Y., Iwami, Y., Takahashi, N. Oral Microbiol. Immunol. (2006) [Pubmed]
  23. Direct pulp capping with a dentin bonding system in human teeth: a clinical and histological evaluation. Silva, G.A., Lanza, L.D., Lopes-Júnior, N., Moreira, A., Alves, J.B. Operative dentistry. (2006) [Pubmed]
  24. Nanoparticles of calcium hydroxide for wood conservation. The deacidification of the Vasa warship. Giorgi, R., Chelazzi, D., Baglioni, P. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  25. Intraoral comparison of calcium hydroxide (Calnex) alone and in combination with Ledermix in first permanent mandibular molars using two direct inspection criteria. Santini, A.H. Journal of dentistry. (1985) [Pubmed]
  26. In vitro effects of calcium hydroxide and polymyxin B on endotoxins in root canals. Oliveira, L.D., Leão, M.V., Carvalho, C.A., Camargo, C.H., Valera, M.C., Jorge, A.O., Unterkircher, C.S. Journal of dentistry. (2005) [Pubmed]
  27. TGF-beta 1 alone and in combination with calcium hydroxide is synergistic to TGF-beta 1 production by osteoblasts in vitro. Jaunberzins, A., Gutmann, J.L., Witherspoon, D.E., Harper, R.P. International endodontic journal. (2000) [Pubmed]
  28. Immunohistochemical expression of fibronectin and tenascin after direct pulp capping with calcium hydroxide. Piva, E., Tarquínio, S.B., Demarco, F.F., Silva, A.F., de Araújo, V.C. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2006) [Pubmed]
  29. Thermal conductivity through various restorative lining materials. Little, P.A., Wood, D.J., Bubb, N.L., Maskill, S.A., Mair, L.H., Youngson, C.C. Journal of dentistry. (2005) [Pubmed]
  30. Short-term evaluation of the pulpo-dentin complex response to a resin-modified glass-ionomer cement and a bonding agent applied in deep cavities. Costa, C.A., Giro, E.M., do Nascimento, A.B., Teixeira, H.M., Hebling, J. Dental materials : official publication of the Academy of Dental Materials. (2003) [Pubmed]
  31. Current and potential pulp therapies for primary and young permanent teeth. Ranly, D.M., Garcia-Godoy, F. Journal of dentistry. (2000) [Pubmed]
  32. Oral administration of calcium hydroxide stimulates bone metabolism in the femoral diaphysis of rats with skeletal unloading. Yamaguchi, M., Shimokawa, N., Hoshi, T. Chem. Pharm. Bull. (1991) [Pubmed]
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