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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?

Neuronal intranuclear inclusions have been found in the brain of a transgenic mouse model of Huntington's disease and in necropsy brain tissue of patients with Huntington's disease. We suggest that neuronal intranuclear inclusions are the common neuropathology for all inherited diseases caused by expansion of polyglutamine repeats. We also suggest that patients with a pathological diagnosis of neuronal intranuclear hyaline inclusion disease may also have polyglutamine repeat expansions.[1]

References

  1. Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions? Davies, S.W., Beardsall, K., Turmaine, M., DiFiglia, M., Aronin, N., Bates, G.P. Lancet (1998) [Pubmed]
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