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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Hyalin


High impact information on Hyalin

  • The c-Abl protein is a non-receptor tyrosine kinase involved in many aspects of mammalian development. c-Abl kinase is widely expressed, but high levels are found in hyaline cartilage in the adult, bone tissue in newborn mice, and osteoblasts and associated neovasculature at sites of endochondrial ossification in the fetus [6].
  • The first response to cyclic AMP is a locally generated extension of a hyaline pseudopod from the region of the surface nearest the stimulus [7].
  • Prevention of hyaline membrane disease with plasminogen. A cooperative study [8].
  • We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cartilages and joints of transgenic mice [9].
  • These observations provide clear and novel evidence for the pathogenic contribution of PAI-1 in the development of hyaline membrane disease [10].

Chemical compound and disease context of Hyalin


Biological context of Hyalin

  • To explore whether increased PAI-1 production is a causal or only a correlative event for impaired intraalveolar fibrinolysis and the development of hyaline membrane disease, we studied mice genetically deficient in PAI-1 [10].
  • Double label immunofluorescent staining of frozen sections of ovary with the SCS antiserum and an antibody to the cortical granule protein hyalin indicated a dramatic morphogenesis of the SCS-containing ER (SCS-ER) coincident with oocyte maturation [16].
  • Conversion to an elastogenic phenotype by fetal hyaline chondrocytes is accompanied by altered expression of elastin-related macromolecules [17].
  • We report a case of hyaline vascular Castleman's disease with intragenic HMGIC rearrangement, due to a clonal cytogenetic aberration involving the long arm of chromosome 12 [46,XX, add(1)(q21),der(6)t(6;12) (q23;q15),add(7)(p22), -9,inv(9)(p11q13),del(12)(q15),+mar] obtained after short-term primary cultures [18].
  • Given the known angiogenic and vascular permeability activities of VEGF, we propose that VEGF plays an important role in molding the characteristic morphologic features of this tumor, namely, the formation of cysts, microcystic pattern, hyaline cystic degeneration, hyaline vessels, and vascular proliferation [19].

Anatomical context of Hyalin


Associations of Hyalin with chemical compounds

  • 41 mechanically ventilated babies who had been treated with surfactant (Curosurf) for hyaline membrane disease were randomly assigned morphine in 5% dextrose (100 micrograms/kg per h for 2 h followed by 25 micrograms/kg per h continuous infusion) or 5% dextrose (placebo) [24].
  • Pancuronium during mechanical ventilation speeds recovery of lungs of infants with hyaline membrane disease [25].
  • The composition of the proteoglycan monomer was different from that of proteoglycan monomer preparations from normal hyaline cartilages in that it did not contain keratan sulfate and chondroitin 6-sulfate; only chondroitin 4-sulfate was found [26].
  • Clonidine treatment resulted in fewer, shorter, and thinner hyaline casts [27].
  • Sodium salicylate has been shown to suppress glycosaminoglycan (GAG) synthesis by articular hyaline cartilage in vitro [28].

Gene context of Hyalin


Analytical, diagnostic and therapeutic context of Hyalin

  • We have generated and characterized a monoclonal antibody (McA Tg-HYL) that recognizes sea urchin hyalin as evidenced by immunofluorescence staining of the hyaline layer (HL) and immunoblot staining of the hyalin protein band [34].
  • Our findings suggest that cell-mediated TGF-beta 1 gene therapy may be a novel treatment for orthopedic diseases in which hyaline cartilage damage has occurred [35].
  • Histological and immunohistochemical staining of the newly repaired tissues produced after treatment with either mixed cells or hChon-TGF-beta1 cells alone showed hyaline cartilage- like characteristics [36].
  • Using quantitative, real-time PCR, we demonstrate that Bcl-2-deficient chondrocytes coordinately down-regulate genes coding for hyaline cartilage matrix proteins including collagen II, collagen IX, aggrecan, and link protein [37].
  • RT-PCR for VEGF mRNA of normal hyaline cartilage was negative [38].


  1. Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity. White, C.W., Avraham, K.B., Shanley, P.F., Groner, Y. J. Clin. Invest. (1991) [Pubmed]
  2. Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions? Davies, S.W., Beardsall, K., Turmaine, M., DiFiglia, M., Aronin, N., Bates, G.P. Lancet (1998) [Pubmed]
  3. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Hanks, S., Adams, S., Douglas, J., Arbour, L., Atherton, D.J., Balci, S., Bode, H., Campbell, M.E., Feingold, M., Keser, G., Kleijer, W., Mancini, G., McGrath, J.A., Muntoni, F., Nanda, A., Teare, M.D., Warman, M., Pope, F.M., Superti-Furga, A., Futreal, P.A., Rahman, N. Am. J. Hum. Genet. (2003) [Pubmed]
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  5. Chronic cyclosporin A nephrotoxicity, P-glycoprotein overexpression, and relationships with intrarenal angiotensin II deposits. del Moral, R.G., Andujar, M., Ramírez, C., Gómez-Morales, M., Masseroli, M., Aguilar, M., Olmo, A., Arrebola, F., Guillén, M., García-Chicano, M.J., Nogales, F.F., O'Valle, F. Am. J. Pathol. (1997) [Pubmed]
  6. Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Li, B., Boast, S., de los Santos, K., Schieren, I., Quiroz, M., Teitelbaum, S.L., Tondravi, M.M., Goff, S.P. Nat. Genet. (2000) [Pubmed]
  7. Local and spatially coordinated movements in Dictyostelium discoideum amoebae during chemotaxis. Swanson, J.A., Taylor, D.L. Cell (1982) [Pubmed]
  8. Prevention of hyaline membrane disease with plasminogen. A cooperative study. Ambrus, C.M., Choi, T.S., Cunnanan, E., Eisenberg, B., Staub, H.P., Weintraub, D.H., Courey, N.G., Patterson, R.J., Jockin, H., Pickren, J.W., Bross, I.D., Jung, O.S., Ambrus, J.L. JAMA (1977) [Pubmed]
  9. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. Neuhold, L.A., Killar, L., Zhao, W., Sung, M.L., Warner, L., Kulik, J., Turner, J., Wu, W., Billinghurst, C., Meijers, T., Poole, A.R., Babij, P., DeGennaro, L.J. J. Clin. Invest. (2001) [Pubmed]
  10. Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. Barazzone, C., Belin, D., Piguet, P.F., Vassalli, J.D., Sappino, A.P. J. Clin. Invest. (1996) [Pubmed]
  11. Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis. Konttinen, Y.T., Mandelin, J., Li, T.F., Salo, J., Lassus, J., Liljeström, M., Hukkanen, M., Takagi, M., Virtanen, I., Santavirta, S. Arthritis Rheum. (2002) [Pubmed]
  12. Familial amyotrophic lateral sclerosis with a novel Leu126Ser mutation in the copper/zinc superoxide dismutase gene showing mild clinical features and lewy body-like hyaline inclusions. Takehisa, Y., Ujike, H., Ishizu, H., Terada, S., Haraguchi, T., Tanaka, Y., Nishinaka, T., Nobukuni, K., Ihara, Y., Namba, R., Yasuda, T., Nishibori, M., Hayabara, T., Kuroda, S. Arch. Neurol. (2001) [Pubmed]
  13. Kaposi-like infantile hemangioendothelioma. A distinctive vascular neoplasm of the retroperitoneum. Tsang, W.Y., Chan, J.K. Am. J. Surg. Pathol. (1991) [Pubmed]
  14. Hyalinizing trabecular adenoma of the thyroid gland. Carney, J.A., Ryan, J., Goellner, J.R. Am. J. Surg. Pathol. (1987) [Pubmed]
  15. Reduced incidence of hyaline membrane disease in extremely premature infants following delay of delivery in mother with preterm labor: use of ritodrine and betamethasone. Kwong, M.S., Egan, E.A. Pediatrics (1986) [Pubmed]
  16. Differentiation of a calsequestrin-containing endoplasmic reticulum during sea urchin oogenesis. Henson, J.H., Beaulieu, S.M., Kaminer, B., Begg, D.A. Dev. Biol. (1990) [Pubmed]
  17. Conversion to an elastogenic phenotype by fetal hyaline chondrocytes is accompanied by altered expression of elastin-related macromolecules. Lee, K.A., Pierce, R.A., Davis, E.C., Mecham, R.P., Parks, W.C. Dev. Biol. (1994) [Pubmed]
  18. Hyaline vascular Castleman's disease with HMGIC rearrangement in follicular dendritic cells: molecular evidence of mesenchymal tumorigenesis. Cokelaere, K., Debiec-Rychter, M., De Wolf-Peeters, C., Hagemeijer, A., Sciot, R. Am. J. Surg. Pathol. (2002) [Pubmed]
  19. Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. Leung, S.Y., Chan, A.S., Wong, M.P., Yuen, S.T., Cheung, N., Chung, L.P. Am. J. Surg. Pathol. (1997) [Pubmed]
  20. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Nakayama, N., Han, C.Y., Cam, L., Lee, J.I., Pretorius, J., Fisher, S., Rosenfeld, R., Scully, S., Nishinakamura, R., Duryea, D., Van, G., Bolon, B., Yokota, T., Zhang, K. Development (2004) [Pubmed]
  21. Release of pyrophosphate by normal mammalian articular hyaline and fibrocartilage in organ culture. Ryan, L.M., Cheung, H.S., McCarty, D.J. Arthritis Rheum. (1981) [Pubmed]
  22. Electrical charge of the antigen determines its localization in the mouse knee joint. Deep penetration of cationic BSA in hyaline articular cartilage. van den Berg, W.B., van de Putte, L.B. Am. J. Pathol. (1985) [Pubmed]
  23. Cytoplasmic filaments of Crooke's hyaline change belong to the cytokeratin class. An immunocytochemical and ultrastructural study. Neumann, P.E., Horoupian, D.S., Goldman, J.E., Hess, M.A. Am. J. Pathol. (1984) [Pubmed]
  24. Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies. Quinn, M.W., Wild, J., Dean, H.G., Hartley, R., Rushforth, J.A., Puntis, J.W., Levene, M.I. Lancet (1993) [Pubmed]
  25. Pancuronium during mechanical ventilation speeds recovery of lungs of infants with hyaline membrane disease. Pollitzer, M.J., Reynolds, E.O., Shaw, D.G., Thomas, R.M. Lancet (1981) [Pubmed]
  26. Isolation and characterization of proteoglycans from the swarm rat chondrosarcoma. Oegema, T.R., Hascall, V.C., Dziewiatkowski, D.D. J. Biol. Chem. (1975) [Pubmed]
  27. The effect of clonidine on tubular obstruction in postischemic acute renal failure in the rabbit demonstrated by microradiography and microdissection. Ideura, T., Solez, K., Heptinstall, R.H. Am. J. Pathol. (1980) [Pubmed]
  28. Salicylate-induced depletion of endogenous inorganic sulfate. Potential role in the suppression of sulfated glycosaminoglycan synthesis in murine articular cartilage. de Vries, B.J., van den Berg, W.B., van de Putte, L.B. Arthritis Rheum. (1985) [Pubmed]
  29. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Dowling, O., Difeo, A., Ramirez, M.C., Tukel, T., Narla, G., Bonafe, L., Kayserili, H., Yuksel-Apak, M., Paller, A.S., Norton, K., Teebi, A.S., Grum-Tokars, V., Martin, G.S., Davis, G.E., Glucksman, M.J., Martignetti, J.A. Am. J. Hum. Genet. (2003) [Pubmed]
  30. The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Pufe, T., Petersen, W., Tillmann, B., Mentlein, R. Arthritis Rheum. (2001) [Pubmed]
  31. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. Miyazaki, K., Fujita, T., Ozaki, T., Kato, C., Kurose, Y., Sakamoto, M., Kato, S., Goto, T., Itoyama, Y., Aoki, M., Nakagawara, A. J. Biol. Chem. (2004) [Pubmed]
  32. Expression of prohormone convertase, PC2, in adrenocorticotropin-producing thymic carcinoid with elevated plasma corticotropin-releasing hormone. Kimura, N., Ishikawa, T., Sasaki, Y., Sasano, N., Onodera, K., Shimizu, Y., Kimura, I., Steiner, D.F., Nagura, H. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  33. TGFbeta2 in corneal morphogenesis during mouse embryonic development. Saika, S., Saika, S., Liu, C.Y., Azhar, M., Sanford, L.P., Doetschman, T., Gendron, R.L., Kao, C.W., Kao, W.W. Dev. Biol. (2001) [Pubmed]
  34. Sea urchin morphogenesis and cell-hyalin adhesion are perturbed by a monoclonal antibody specific for hyalin. Adelson, D.L., Humphreys, T. Development (1988) [Pubmed]
  35. Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor beta 1-producing fibroblasts. Lee, K.H., Song, S.U., Hwang, T.S., Yi, Y., Oh, I.S., Lee, J.Y., Choi, K.B., Choi, M.S., Kim, S.J. Hum. Gene Ther. (2001) [Pubmed]
  36. Hyaline cartilage regeneration using mixed human chondrocytes and transforming growth factor-beta1- producing chondrocytes. Song, S.U., Cha, Y.D., Han, J.U., Oh, I.S., Choi, K.B., Yi, Y., Hyun, J.P., Lee, H.Y., Chi, G.F., Lim, C.L., Ganjei, J.K., Noh, M.J., Kim, S.J., Lee, D.K., Lee, K.H. Tissue engineering. (2005) [Pubmed]
  37. Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability. Kinkel, M.D., Horton, W.E. J. Cell. Biochem. (2003) [Pubmed]
  38. Expression of VEGF121 and VEGF165 in hypertrophic chondrocytes of the human growth plate and epiphyseal cartilage. Petersen, W., Tsokos, M., Pufe, T. J. Anat. (2002) [Pubmed]
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