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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Brief, transient Horner's syndrome can be the hallmark of a carotid artery dissection.

We describe a 41-year-old woman in whom the diagnosis of carotid artery dissection was suspected based on a recent history of anisocoria and ipsilateral ptosis that lasted 2 days. She had a normal neurologic examination, including no clinical evidence of anisocoria or ptosis. Subsequently, a cocaine test demonstrated pharmacologic Horner's syndrome. MRI confirmed the carotid dissection. This patient illustrates that a history of transient pupillary and eyelid abnormalities can lead to the diagnosis of a carotid dissection. Specific questioning about transient anisocoria and ptosis should be considered when a carotid artery dissection is suspected. Pharmacologic testing may be a useful tool in such instances.[1]


  1. Brief, transient Horner's syndrome can be the hallmark of a carotid artery dissection. Leira, E.C., Bendixen, B.H., Kardon, R.H., Adams, H.P. Neurology (1998) [Pubmed]
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