Disease relevance of Anisocoria

• Anisocoria and ipsilateral exophthalmos during enflurane anesthesia [1].
• This is the first Hemicrania continua case to be documented in Spain. The tyramine test resulted in anisocoria with the smaller pupil on the symptomatic side [2].
• In cluster headache, the extent of nonresponsiveness to OH-amphetamine and of phenylephrine supersensitivity on the symptomatic side thus, at least partly, seems to be a function of the degree of anisocoria [3].
• The chances of having Horner's syndrome increased with the amount of cocaine-induced anisocoria [4].
• This study demonstrates that in a CH group 2% tyramine (an intraneuronal norepinephrine releaser) instillation into both eyes induces an asymmetric and bilateral mydriasis with the onset of anisocoria characterized by a pupillary diameter being less on the pain-side eye [5].

High impact information on Anisocoria

• METHODS: The right pupil of 42 normal subjects was first dilated with phenylephrine to create an experimental anisocoria [6].
• CONCLUSION: Pupil size, degree of anisocoria, and light conditions influence the amount of pilocarpine-induced change in anisocoria [6].
• A second tyramine test after one week on 75 mg indomethacin per day failed to produce anisocoria [2].
• We compared the cocaine-induced anisocoria in the two groups by measuring photographs of the pupils [4].
• In five rabbits with unilateral superior cervical ganglionectomies, bilateral 5% cocaine HCl or E-10-hydroxynortriptyline maleate eye drops increased (P less than 0.001) the mean +/- SE anisocoria at 1 h by 1.84 +/- 0.03 mm or 2.16 +/- 0.33 mm, respectively [7].

Chemical compound and disease context of Anisocoria

• Bilateral instillation of tyramine in the conjunctival sac resulted in a late appearing anisocoria, with the smaller pupil on the symptomatic side [8].
• BACKGROUND: This study determines how pupil size, anisocoria, and ambient light influence miotic responses to dilute pilocarpine [6].
• In CH patients, pretreatment with clonidine augments the degree of anisocoria induced by tyramine instillation, increasing the mydriatic response only in the pain-free-side pupil [5].
• Changes in the fundal reflections, seen in the photographs taken as the infant views the different targets, can be interpreted unequivocally to identify severe myopia and hyperopia, anisometropia, heterotropia, and anisocoria [9].
• Transient anisocoria secondary to nebulized ipratropium bromide [10].

Gene context of Anisocoria

• Ataxia (88%), decreased withdrawal reflexes (88%), proprioceptive deficits (81%), decreased vent responses (69%), beak or tongue weakness (42%), and head tremors (31%), as well as absent pupillary light responses (46%), anisocoria (15%), apparent blindness (4%), nystagmus (4%), and strabismus (4%) were detected [11].
• Abnormal BAEPs showed a significant correlation with absence of pupillary and/or corneal reflex, but not with the Glasgow Coma Score and anisocoria [12].
• Suggestions are given for a simple "Naloxone Anisocoria Test" for the presence or absence of elevated endogenous opiates [13].

Analytical, diagnostic and therapeutic context of Anisocoria

• Postoperative anisocoria: neurogenic or phenylephrine induced? A rapid diagnostic test [14].
• PURPOSE: To report the incidence of anisocoria after unilateral excimer laser photorefractive keratectomy (PRK) for myopia and subsequent corticosteroid therapy in a retrospective and prospective study and to explore possible etiologies [15].
• Ipratropium-bromide-induced acute anisocoria in the intensive care setting due to ill-fitting face masks [16].
• Neurological examination however, revealed anisocoria, his left pupil being smaller than his right, and a Brown-Sequard syndrome, with a sensory level at C6 [17].

References