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MeSH Review


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Disease relevance of Anisocoria


High impact information on Anisocoria


Chemical compound and disease context of Anisocoria

  • Bilateral instillation of tyramine in the conjunctival sac resulted in a late appearing anisocoria, with the smaller pupil on the symptomatic side [8].
  • BACKGROUND: This study determines how pupil size, anisocoria, and ambient light influence miotic responses to dilute pilocarpine [6].
  • In CH patients, pretreatment with clonidine augments the degree of anisocoria induced by tyramine instillation, increasing the mydriatic response only in the pain-free-side pupil [5].
  • Changes in the fundal reflections, seen in the photographs taken as the infant views the different targets, can be interpreted unequivocally to identify severe myopia and hyperopia, anisometropia, heterotropia, and anisocoria [9].
  • Transient anisocoria secondary to nebulized ipratropium bromide [10].

Gene context of Anisocoria

  • Ataxia (88%), decreased withdrawal reflexes (88%), proprioceptive deficits (81%), decreased vent responses (69%), beak or tongue weakness (42%), and head tremors (31%), as well as absent pupillary light responses (46%), anisocoria (15%), apparent blindness (4%), nystagmus (4%), and strabismus (4%) were detected [11].
  • Abnormal BAEPs showed a significant correlation with absence of pupillary and/or corneal reflex, but not with the Glasgow Coma Score and anisocoria [12].
  • Suggestions are given for a simple "Naloxone Anisocoria Test" for the presence or absence of elevated endogenous opiates [13].

Analytical, diagnostic and therapeutic context of Anisocoria


  1. Anisocoria and ipsilateral exophthalmos during enflurane anesthesia. Klein, D.S., Kosanin, R. Anesthesiology (1982) [Pubmed]
  2. Hemicrania continua. The first Spanish case: a case report. Pareja, J.A., Palomo, T., Gorriti, M.A., Pareja, J., Espejo, J., Morón, B., Trigo, M. Cephalalgia : an international journal of headache. (1990) [Pubmed]
  3. Cluster headache: pupillometric patterns as a function of the degree of anisocoria. Salvesen, R., Sand, T., Zhao, J.M., Sjaastad, O. Cephalalgia : an international journal of headache. (1989) [Pubmed]
  4. Critical evaluation of the cocaine test in the diagnosis of Horner's syndrome. Kardon, R.H., Denison, C.E., Brown, C.K., Thompson, H.S. Arch. Ophthalmol. (1990) [Pubmed]
  5. Does anisocoria by clonidine reflect a central sympathetic dysfunction in cluster headache? Fanciullacci, M., Pietrini, U., Fusco, B.M., Alessandri, M., Marabini, S., Sicuteri, F. Clinical neuropharmacology. (1988) [Pubmed]
  6. Influence of pupil size, anisocoria, and ambient light on pilocarpine miosis. Implications for supersensitivity testing. Jacobson, D.M., Olson, K.A. Ophthalmology (1993) [Pubmed]
  7. The pupil response to E-10-hydroxynortriptyline in rabbits with ocular sympathetic paresis. Mindel, J.S., Rubin, M.A., Kharlamb, A.B. J. Auton. Nerv. Syst. (1990) [Pubmed]
  8. "Hemicrania continua". An indomethacin responsive headache. II. Autonomic function studies. Sjaastad, O., Spierings, E.L., Saunte, C., Wysocka Bakowska, M.M., Sulg, I., Fredriksen, T.A. Cephalalgia : an international journal of headache. (1984) [Pubmed]
  9. Screening infant vision with paraxial photorefraction. Abramov, I., Hainline, L., Duckman, R.H. Optometry and vision science : official publication of the American Academy of Optometry. (1990) [Pubmed]
  10. Transient anisocoria secondary to nebulized ipratropium bromide. Cabana, M.D., Johnson, H., Lee, C.K., Helfaer, M. Clinical pediatrics. (1998) [Pubmed]
  11. Clinical features of avian vacuolar myelinopathy in American coots. Larsen, R.S., Nutter, F.B., Augspurger, T., Rocke, T.E., Tomlinson, L., Thomas, N.J., Stoskopf, M.K. J. Am. Vet. Med. Assoc. (2002) [Pubmed]
  12. Predictive value of brain-stem auditory evoked potentials in children with post-traumatic coma produced by diffuse brain injury. Bosch Blancafort, J., Olesti Marco, M., Poch Puig, J.M., Rubio García, E., Nogués Bara, P., Iglesias Berenguer, J. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1995) [Pubmed]
  13. Naloxone eye drops reverse the miosis in runners--implications for an endogenous opiate test. Allen, M., Thierman, J., Hamilton, D. Canadian journal of applied sport sciences. Journal canadien des sciences appliquées au sport. (1983) [Pubmed]
  14. Postoperative anisocoria: neurogenic or phenylephrine induced? A rapid diagnostic test. Sitzman, B.T., Bogdonoff, D.L., Bleck, T.P., Spiekermann, B.F., Chang, C.W. Anesth. Analg. (1996) [Pubmed]
  15. Relative mydriasis after photorefractive keratectomy. Geerling, G., Neppert, B., Wirbelauer, C., Laqua, H. Journal of refractive surgery (Thorofare, N.J. : 1995) (2000) [Pubmed]
  16. Ipratropium-bromide-induced acute anisocoria in the intensive care setting due to ill-fitting face masks. Bisquerra, R.A., Botz, G.H., Nates, J.L. Respiratory care. (2005) [Pubmed]
  17. A case of Brown-Sequard syndrome with associated Horner's syndrome after blunt injury to the cervical spine. Edwards, A., Andrews, R. Emergency medicine journal : EMJ. (2001) [Pubmed]
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