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MeSH Review

Carotid Arteries

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Disease relevance of Carotid Arteries


High impact information on Carotid Arteries

  • The DNA enzyme also inhibited Egr-1 induction and neointima formation after balloon injury to the rat carotid artery wall [6].
  • CP-96,345 inhibited 3H-labeled substance P binding and was a classical competitive antagonist in the NK1 monoreceptor dog carotid artery preparation [7].
  • Localized delivery of the virus to denuded rat carotid arteries significantly reduced neointima formation and luminal narrowing [8].
  • OBJECTIVE: To compare the rate of progression of mean maximum intimal-medial thickness (IMT) in carotid arteries, using quantitative B-mode ultrasound imaging, during antihypertensive therapy with isradipine vs hydrochlorothiazide [9].
  • Here we report that a brief exposure to either alkyl ether analogs of the growth factor-like phospholipid lysophosphatidic acid (LPA), products generated during the oxidative modification of low density lipoprotein, or to unsaturated acyl forms of LPA induce progressive formation of neointima in vivo in a rat carotid artery model [10].

Chemical compound and disease context of Carotid Arteries


Biological context of Carotid Arteries


Anatomical context of Carotid Arteries


Associations of Carotid Arteries with chemical compounds


Gene context of Carotid Arteries


Analytical, diagnostic and therapeutic context of Carotid Arteries


  1. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. Selhub, J., Jacques, P.F., Bostom, A.G., D'Agostino, R.B., Wilson, P.W., Belanger, A.J., O'Leary, D.H., Wolf, P.A., Schaefer, E.J., Rosenberg, I.H. N. Engl. J. Med. (1995) [Pubmed]
  2. Stroke in rats produced by carotid injection of sodium arachidonate. Furlow, T.W., Bass, N.H. Science (1975) [Pubmed]
  3. Aberrant carotid artery injured at myringotomy. Control of hemorrhage by a balloon catheter. Reilly, J.J., Caparosa, R.J., Latchaw, R.E., Sheptak, P.E. JAMA (1983) [Pubmed]
  4. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. HajMohammadi, S., Enjyoji, K., Princivalle, M., Christi, P., Lech, M., Beeler, D., Rayburn, H., Schwartz, J.J., Barzegar, S., de Agostini, A.I., Post, M.J., Rosenberg, R.D., Shworak, N.W. J. Clin. Invest. (2003) [Pubmed]
  5. Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model. Simons, M., Edelman, E.R., Rosenberg, R.D. J. Clin. Invest. (1994) [Pubmed]
  6. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Santiago, F.S., Lowe, H.C., Kavurma, M.M., Chesterman, C.N., Baker, A., Atkins, D.G., Khachigian, L.M. Nat. Med. (1999) [Pubmed]
  7. A potent nonpeptide antagonist of the substance P (NK1) receptor. Snider, R.M., Constantine, J.W., Lowe, J.A., Longo, K.P., Lebel, W.S., Woody, H.A., Drozda, S.E., Desai, M.C., Vinick, F.J., Spencer, R.W. Science (1991) [Pubmed]
  8. p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Smith, R.C., Branellec, D., Gorski, D.H., Guo, K., Perlman, H., Dedieu, J.F., Pastore, C., Mahfoudi, A., Denèfle, P., Isner, J.M., Walsh, K. Genes Dev. (1997) [Pubmed]
  9. Final outcome results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). A randomized controlled trial. Borhani, N.O., Mercuri, M., Borhani, P.A., Buckalew, V.M., Canossa-Terris, M., Carr, A.A., Kappagoda, T., Rocco, M.V., Schnaper, H.W., Sowers, J.R., Bond, M.G. JAMA (1996) [Pubmed]
  10. Lysophosphatidic acid induces neointima formation through PPARgamma activation. Zhang, C., Baker, D.L., Yasuda, S., Makarova, N., Balazs, L., Johnson, L.R., Marathe, G.K., McIntyre, T.M., Xu, Y., Prestwich, G.D., Byun, H.S., Bittman, R., Tigyi, G. J. Exp. Med. (2004) [Pubmed]
  11. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. van Vlijmen, B.J., van den Maagdenberg, A.M., Gijbels, M.J., van der Boom, H., HogenEsch, H., Frants, R.R., Hofker, M.H., Havekes, L.M. J. Clin. Invest. (1994) [Pubmed]
  12. Local delivery of r-hirudin by a double-balloon perfusion catheter prevents mural thrombosis and minimizes platelet deposition after angioplasty. Meyer, B.J., Fernández-Ortiz, A., Mailhac, A., Falk, E., Badimon, L., Michael, A.D., Chesebro, J.H., Fuster, V., Badimon, J.J. Circulation (1994) [Pubmed]
  13. Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries. Salonen, R., Nyyssönen, K., Porkkala, E., Rummukainen, J., Belder, R., Park, J.S., Salonen, J.T. Circulation (1995) [Pubmed]
  14. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Furberg, C.D., Adams, H.P., Applegate, W.B., Byington, R.P., Espeland, M.A., Hartwell, T., Hunninghake, D.B., Lefkowitz, D.S., Probstfield, J., Riley, W.A. Circulation (1994) [Pubmed]
  15. Inhibition of thrombosis and intimal thickening by in situ photopolymerization of thin hydrogel barriers. Hill-West, J.L., Chowdhury, S.M., Slepian, M.J., Hubbell, J.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. Chang, M.W., Barr, E., Lu, M.M., Barton, K., Leiden, J.M. J. Clin. Invest. (1995) [Pubmed]
  17. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Ohlstein, E.H., Nambi, P., Douglas, S.A., Edwards, R.M., Gellai, M., Lago, A., Leber, J.D., Cousins, R.D., Gao, A., Frazee, J.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  18. Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening. Abe, J., Deguchi, J., Matsumoto, T., Takuwa, N., Noda, M., Ohno, M., Makuuchi, M., Kurokawa, K., Takuwa, Y. Circulation (1997) [Pubmed]
  19. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Fontana, L., Meyer, T.E., Klein, S., Holloszy, J.O. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Ventricular receptors activated following myocardial prostaglandin synthesis initiate reflex hypotension, reduction in heart rate, and redistribution of cardiac output in the dog. Hintze, T.H., Kaley, G. Circ. Res. (1984) [Pubmed]
  21. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. Massberg, S., Brand, K., Grüner, S., Page, S., Müller, E., Müller, I., Bergmeier, W., Richter, T., Lorenz, M., Konrad, I., Nieswandt, B., Gawaz, M. J. Exp. Med. (2002) [Pubmed]
  22. Production of transforming growth factor beta 1 during repair of arterial injury. Majesky, M.W., Lindner, V., Twardzik, D.R., Schwartz, S.M., Reidy, M.A. J. Clin. Invest. (1991) [Pubmed]
  23. Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury. Jain, M., He, Q., Lee, W.S., Kashiki, S., Foster, L.C., Tsai, J.C., Lee, M.E., Haber, E. J. Clin. Invest. (1996) [Pubmed]
  24. The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. Huo, Y., Weber, C., Forlow, S.B., Sperandio, M., Thatte, J., Mack, M., Jung, S., Littman, D.R., Ley, K. J. Clin. Invest. (2001) [Pubmed]
  25. Estrogen restores endothelial cell function in an experimental model of vascular injury. White, C.R., Shelton, J., Chen, S.J., Darley-Usmar, V., Allen, L., Nabors, C., Sanders, P.W., Chen, Y.F., Oparil, S. Circulation (1997) [Pubmed]
  26. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. Lentz, S.R., Sobey, C.G., Piegors, D.J., Bhopatkar, M.Y., Faraci, F.M., Malinow, M.R., Heistad, D.D. J. Clin. Invest. (1996) [Pubmed]
  27. Inhibition of smooth muscle cell proliferation in injured rat arteries. Interaction of heparin with basic fibroblast growth factor. Lindner, V., Olson, N.E., Clowes, A.W., Reidy, M.A. J. Clin. Invest. (1992) [Pubmed]
  28. Estrogen inhibits the response-to-injury in a mouse carotid artery model. Sullivan, T.R., Karas, R.H., Aronovitz, M., Faller, G.T., Ziar, J.P., Smith, J.J., O'Donnell, T.F., Mendelsohn, M.E. J. Clin. Invest. (1995) [Pubmed]
  29. Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment. Buchanan, M.R., Dejana, E., Gent, M., Mustard, J.F., Hirsch, J. J. Clin. Invest. (1981) [Pubmed]
  30. Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. Kannan, R., Kuhlenkamp, J.F., Jeandidier, E., Trinh, H., Ookhtens, M., Kaplowitz, N. J. Clin. Invest. (1990) [Pubmed]
  31. The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. Hou, G., Vogel, W., Bendeck, M.P. J. Clin. Invest. (2001) [Pubmed]
  32. Endothelin-converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis. Minamino, T., Kurihara, H., Takahashi, M., Shimada, K., Maemura, K., Oda, H., Ishikawa, T., Uchiyama, T., Tanzawa, K., Yazaki, Y. Circulation (1997) [Pubmed]
  33. Local gene transfer of tissue factor pathway inhibitor regulates intimal hyperplasia in atherosclerotic arteries. Zoldhelyi, P., Chen, Z.Q., Shelat, H.S., McNatt, J.M., Willerson, J.T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  34. Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteries. Jenkins, G.M., Crow, M.T., Bilato, C., Gluzband, Y., Ryu, W.S., Li, Z., Stetler-Stevenson, W., Nater, C., Froehlich, J.P., Lakatta, E.G., Cheng, L. Circulation (1998) [Pubmed]
  35. Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function. Meek, R.L., Urieli-Shoval, S., Benditt, E.P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  36. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. Bennett, M.R., Anglin, S., McEwan, J.R., Jagoe, R., Newby, A.C., Evan, G.I. J. Clin. Invest. (1994) [Pubmed]
  37. H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury. Kim, D.K., Zhang, L., Dzau, V.J., Pratt, R.E. J. Clin. Invest. (1994) [Pubmed]
  38. Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. van Dam, M.J., de Groot, E., Clee, S.M., Hovingh, G.K., Roelants, R., Brooks-Wilson, A., Zwinderman, A.H., Smit, A.J., Smelt, A.H., Groen, A.K., Hayden, M.R., Kastelein, J.J. Lancet (2002) [Pubmed]
  39. Subacute thrombosis and vascular injury resulting from slotted-tube nitinol and stainless steel stents in a rabbit carotid artery model. Sheth, S., Litvack, F., Dev, V., Fishbein, M.C., Forrester, J.S., Eigler, N. Circulation (1996) [Pubmed]
  40. Inhibition of intimal hyperplasia after balloon injury by antibodies to intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1. Yasukawa, H., Imaizumi, T., Matsuoka, H., Nakashima, A., Morimatsu, M. Circulation (1997) [Pubmed]
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