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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Satigrel, a new antiplatelet agent, inhibits platelet accumulation in prosthetic arterial grafts.

BACKGROUND: Early and late vascular obstruction are both related to platelet adhesion and aggregation in the grafts. We assessed the effect of satigrel, a new oral antiplatelet agent, on the accumulation of indium-labeled platelets in knitted Dacron grafts inserted proximal to the femoral artery. METHODS: Nine patients with arteriosclerosis obliterans receiving grafts were treated with satigrel, and 10 others were enrolled as untreated controls. Scintigraphy was performed in postoperative weeks 2 and 4, and the ratio of the scintillation count of the graft to that of the native artery was calculated to assess platelet accumulation. RESULTS: In both weeks 2 and 4, the ratio was significantly smaller in the satigrel group than in the control group for the whole graft, the proximal anastomosis, and the distal anastomosis. CONCLUSIONS: Satigrel significantly inhibited platelet accumulation in vascular grafts and thus may be useful for preventing postoperative graft occlusion.[1]

References

  1. Satigrel, a new antiplatelet agent, inhibits platelet accumulation in prosthetic arterial grafts. Esato, K., Kubo, Y., Yasuda, K., Shigematsu, H., Iwai, T., Ishimaru, S., Uchida, H., Ishii, K. Am. J. Surg. (1998) [Pubmed]
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