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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Alopecia universalis associated with a mutation in the human hairless gene.

There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.[1]


  1. Alopecia universalis associated with a mutation in the human hairless gene. Ahmad, W., Faiyaz ul Haque, M., Brancolini, V., Tsou, H.C., ul Haque, S., Lam, H., Aita, V.M., Owen, J., deBlaquiere, M., Frank, J., Cserhalmi-Friedman, P.B., Leask, A., McGrath, J.A., Peacocke, M., Ahmad, M., Ott, J., Christiano, A.M. Science (1998) [Pubmed]
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