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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Expressions of E-cadherin and alpha- and beta-catenin mRNAs in uterine endometrial cancers.

To know the biological function of the adherens junction associated with histological dedifferentiation, intramuscular invasion, and clinical staging, we studied the expressions of E-cadherin and alpha- and beta-catenin mRNAs in endometrial cancers in comparison with those in normal uterine counterparts. As dedifferentiation, myometrial invasion and staging advanced, the expressions of E-cadherin and beta-catenin mRNAs decreased. This suggests that the function of adhesive molecules in the adherens junction might be disturbed, leading to invasiveness and metastatic potential.[1]

References

  1. Expressions of E-cadherin and alpha- and beta-catenin mRNAs in uterine endometrial cancers. Fujimoto, J., Ichigo, S., Hori, M., Tamaya, T. Eur. J. Gynaecol. Oncol. (1998) [Pubmed]
 
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