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Gene Review

AJAP1  -  adherens junctions associated protein 1

Homo sapiens

Synonyms: Adherens junction-associated protein 1, MOT8, Membrane protein shrew-1, SHREW-1, SHREW1
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Disease relevance of AJAP1


High impact information on AJAP1


Biological context of AJAP1


Anatomical context of AJAP1


Other interactions of AJAP1

  • TP73, DFFB and SHREW1 are the only known genes located in these deletion regions, while the others are uncharacterised novel genes [13].


  1. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. Bharti, S., Handrow-Metzmacher, H., Zickenheiner, S., Zeitvogel, A., Baumann, R., Starzinski-Powitz, A. Mol. Biol. Cell (2004) [Pubmed]
  2. Dissociation of intra- and extracellular domains of desmosomal cadherins and E-cadherin in Hailey-Hailey disease and Darier's disease. Hakuno, M., Shimizu, H., Akiyama, M., Amagai, M., Wahl, J.K., Wheelock, M.J., Nishikawa, T. Br. J. Dermatol. (2000) [Pubmed]
  3. Expressions of E-cadherin and alpha- and beta-catenin mRNAs in uterine endometrial cancers. Fujimoto, J., Ichigo, S., Hori, M., Tamaya, T. Eur. J. Gynaecol. Oncol. (1998) [Pubmed]
  4. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. McDonald, J.M., Dunlap, S., Cogdell, D., Dunmire, V., Wei, Q., Starzinski-Powitz, A., Sawaya, R., Bruner, J., Fuller, G.N., Aldape, K., Zhang, W. Cancer Biol. Ther. (2006) [Pubmed]
  5. Usher syndrome: molecular links of pathogenesis, proteins and pathways. Kremer, H., van Wijk, E., Märker, T., Wolfrum, U., Roepman, R. Hum. Mol. Genet. (2006) [Pubmed]
  6. Spatial and temporal distribution of the adherens-junction-associated adhesion molecule A-CAM during avian embryogenesis. Duband, J.L., Volberg, T., Sabanay, I., Thiery, J.P., Geiger, B. Development (1988) [Pubmed]
  7. Targeting of transmembrane protein shrew-1 to adherens junctions is controlled by cytoplasmic sorting motifs. Jakob, V., Schreiner, A., Tikkanen, R., Starzinski-Powitz, A. Mol. Biol. Cell (2006) [Pubmed]
  8. Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma. White, P.S., Thompson, P.M., Gotoh, T., Okawa, E.R., Igarashi, J., Kok, M., Winter, C., Gregory, S.G., Hogarty, M.D., Maris, J.M., Brodeur, G.M. Oncogene (2005) [Pubmed]
  9. Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells. Imamdi, R., de Graauw, M., van de Water, B. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  10. Maximal enzyme activities, and myoglobin and glutathione concentrations in heart, liver and skeletal muscle of the Northern Short-tailed shrew (Blarina brevicauda; Insectivora: Soricidae). Stewart, J.M., Woods, A.K., Blakely, J.A. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  11. Ultrastructural localization of cell junctional components (desmoglein, plakoglobin, E-cadherin, and beta-catenin) in Hailey-Hailey disease, Darier's disease, and pemphigus vulgaris. Tada, J., Hashimoto, K. J. Cutan. Pathol. (1998) [Pubmed]
  12. Isolation of the epidermal growth factor from the shrew submaxillary gland. Yip, T.T., Tam, Y.Y., Kong, Y.C., Belew, M.C., Porath, J. FEBS Lett. (1985) [Pubmed]
  13. Identification of two contiguous minimally deleted regions on chromosome 1p36.31-p36.32 in oligodendroglial tumours. Dong, Z., Pang, J.S., Ng, M.H., Poon, W.S., Zhou, L., Ng, H.K. Br. J. Cancer (2004) [Pubmed]
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