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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae.

A son1 mutant was isolated as a mutant showing synthetic lethality with nin1-1 which is defective in the p31 component of the regulatory subunit of the yeast 26S proteasome. son1delta showed a synthetic effect with sen3delta and sun1delta, both components of the 26S proteasome, and with cdc28-1N. The 26S proteasome was partially purified from the wild type yeast. The FPLC fractions were analyzed by Western blotting using anti-Son1p antibody and antibodies against some authentic subunits of the 26S proteasome, and we found that Son1p co-migrated with components of the 26S proteasome. The 26S proteasome containing fraction was immunoprecipitated with anti-Son1p antibody. The resultant precipitate contained Nin1p, Sun1p, TBP1, and the 20S proteasome. Combining genetic and biochemical results together, we concluded that Son1p is a component of the yeast 26S proteasome.[1]


  1. Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae. Fujimuro, M., Tanaka, K., Yokosawa, H., Toh-e, A. FEBS Lett. (1998) [Pubmed]
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