Dihydroorotate dehydrogenase inhibitors: quantitative structure-activity relationship analysis.
PURPOSE: The main purpose of this study is to analyze the quantitative structure-activity relationship of two series of dihydroorotate dehydrogenase inhibitors (leflunomide and quinoline carboxylic acid analogues), and to determine the structural requirements for optimum activity of these analogues. METHODS: A new CQSAR program was used in deriving regression equations and calculating the octanol/water partition coefficient and the molar refractivity values. The molecular modeling was performed using the HyperChem program. RESULTS: Statistically significant correlations were obtained using a combination of 3-4 parameters. The structural requirements for optimum activity and critical regions for the inhibitory activity of dihydroorotate dehydrogenase were identified. CONCLUSIONS: The quantitative structure-activity relationship analysis demonstrated that two series of dihydroorotate dehydrogenase inhibitors may bind to different binding sites on the enzyme. These results provide a better understanding of dihydroorotate dehydrogenase inhibitor-enzyme interactions, and may be useful for further modification and improvement of inhibitors of this important enzyme.[1]References
- Dihydroorotate dehydrogenase inhibitors: quantitative structure-activity relationship analysis. Ren, S., Wu, S.K., Lien, E.J. Pharm. Res. (1998) [Pubmed]
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