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Gene Review

Dhodh  -  dihydroorotate dehydrogenase

Mus musculus

Synonyms: 2810417D19Rik, AI834883, DHOdehase, Dihydroorotate dehydrogenase (quinone), mitochondrial, Dihydroorotate oxidase
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Anatomical context of Dhodh


Associations of Dhodh with chemical compounds


Analytical, diagnostic and therapeutic context of Dhodh

  • The results are interpreted as supporting the concept that the biosynthetic pathway of pyrimidine (deoxy)nucleotides--because of two oxygen-dependent enzymes, dihydroorotate dehydrogenase and ribonucleotide reductase--is a potential transducer of environmental limitations in oxygen tension to the proliferative capacity of cells [16].


  1. Effect of 6-azauridine on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells. Orotate inhibition of dihydroorotase and dihydroorotate dehydrogenase. Chen, J.J., Jones, M.E. J. Biol. Chem. (1979) [Pubmed]
  2. The "anti-pyrimidine effect" of hypoxia and brequinar sodium (NSC 368390) is of consequence for tumor cell growth. Löffler, M. Biochem. Pharmacol. (1992) [Pubmed]
  3. On the role of dihydroorotate dehydrogenase in growth cessation of Ehrlich ascites tumor cells cultured under oxygen deficiency. Löffler, M. Eur. J. Biochem. (1980) [Pubmed]
  4. Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools. Pizzorno, G., Wiegand, R.A., Lentz, S.K., Handschumacher, R.E. Cancer Res. (1992) [Pubmed]
  5. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium. Xu, X., Williams, J.W., Shen, J., Gong, H., Yin, D.P., Blinder, L., Elder, R.T., Sankary, H., Finnegan, A., Chong, A.S. J. Immunol. (1998) [Pubmed]
  6. In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice. Xu, X., Blinder, L., Shen, J., Gong, H., Finnegan, A., Williams, J.W., Chong, A.S. J. Immunol. (1997) [Pubmed]
  7. Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection. Papageorgiou, C., von Matt, A., Joergensen, J., Andersen, E., Wagner, K., Beerli, C., Than, T., Borer, X., Florineth, A., Rihs, G., Schreier, M.H., Weckbecker, G., Heusser, C. J. Med. Chem. (2001) [Pubmed]
  8. The antilymphocytic activity of brequinar sodium and its potentiation by cytidine. Effects on lymphocyte proliferation and cytokine production. Woo, J., Lemster, B., Tamura, K., Starzl, T.E., Thomson, A.W. Transplantation (1993) [Pubmed]
  9. In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Thomson, T.A., Spinella-Jaegle, S., Francesconi, E., Meakin, C., Millet, S., Flao, K.L., Hidden, H., Ruuth, E. Scand. J. Immunol. (2002) [Pubmed]
  10. Structure-activity relationship of quinoline carboxylic acids. A new class of inhibitors of dihydroorotate dehydrogenase. Chen, S.F., Papp, L.M., Ardecky, R.J., Rao, G.V., Hesson, D.P., Forbes, M., Dexter, D.L. Biochem. Pharmacol. (1990) [Pubmed]
  11. Plasmodium berghei: partial purification and characterization of the mitochondrial cytochrome c oxidase. Krungkrai, J., Krungkrai, S.R., Bhumiratana, A. Exp. Parasitol. (1993) [Pubmed]
  12. Comparative studies on dihydroorotate dehydrogenase from P. berghei and the mouse reticulocyte. Gero, A.M., Finney, K.G., Bennett, J.C., O'Sullivan, W.J. The Australian journal of experimental biology and medical science. (1981) [Pubmed]
  13. Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Krungkrai, J., Krungkrai, S.R., Phakanont, K. Biochem. Pharmacol. (1992) [Pubmed]
  14. Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Xu, X., Williams, J.W., Gong, H., Finnegan, A., Chong, A.S. Biochem. Pharmacol. (1996) [Pubmed]
  15. In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine. Peters, G.J., Kraal, I., Pinedo, H.M. Br. J. Cancer (1992) [Pubmed]
  16. The biosynthetic pathway of pyrimidine (deoxy)nucleotides: a sensor of oxygen tension necessary for maintaining cell proliferation? Löffler, M. Exp. Cell Res. (1989) [Pubmed]
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