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Gene Review

Dhodh  -  dihydroorotate dehydrogenase (quinone)

Rattus norvegicus

Synonyms: DHOdehase, Dihydroorotate dehydrogenase (quinone), mitochondrial, Dihydroorotate oxidase
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Disease relevance of Dhodh

  • A recombinant baculovirus containing the rat liver cDNA for dihydroorotate dehydrogenase was constructed and used for virus infection and protein expression in Trichoplusia ni cells [1].

High impact information on Dhodh


Biological context of Dhodh


Anatomical context of Dhodh


Associations of Dhodh with chemical compounds


Other interactions of Dhodh


Analytical, diagnostic and therapeutic context of Dhodh


  1. Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells. Knecht, W., Altekruse, D., Rotgeri, A., Gonski, S., Löffler, M. Protein Expr. Purif. (1997) [Pubmed]
  2. Suppression of experimental autoimmune neuritis by leflunomide. Korn, T., Toyka, K., Hartung, H.P., Jung, S. Brain (2001) [Pubmed]
  3. Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase. Hines, V., Keys, L.D., Johnston, M. J. Biol. Chem. (1986) [Pubmed]
  4. Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid. Forman, J.H., Kennedy, J. J. Biol. Chem. (1975) [Pubmed]
  5. Leflunomide analogue FK778 is vasculoprotective independent of its immunosuppressive effect: potential applications for restenosis and chronic rejection. Savikko, J., Von Willebrand, E., Häyry, P. Transplantation (2003) [Pubmed]
  6. Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells. Löffler, M., Klein, A., Hayek-Ouassini, M., Knecht, W., Konrad, L. Nucleosides Nucleotides Nucleic Acids (2004) [Pubmed]
  7. Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase. Ittarat, I., Asawamahasakda, W., Bartlett, M.S., Smith, J.W., Meshnick, S.R. Antimicrob. Agents Chemother. (1995) [Pubmed]
  8. In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression. Chong, A.S., Huang, W., Liu, W., Luo, J., Shen, J., Xu, W., Ma, L., Blinder, L., Xiao, F., Xu, X., Clardy, C., Foster, P., Williams, J.A. Transplantation (1999) [Pubmed]
  9. Dihydroorotate dehydrogenase inhibitors: quantitative structure-activity relationship analysis. Ren, S., Wu, S.K., Lien, E.J. Pharm. Res. (1998) [Pubmed]
  10. Anti-peptide immunoglobulins from rabbit and chicken eggs recognise recombinant human dihydroorotate dehydrogenase and a 44-kDa protein from rat liver mitochondria. Knecht, W., Köhler, R., Minét, M., Löffler, M. Eur. J. Biochem. (1996) [Pubmed]
  11. Rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by rat liver cytosolic enzymes. Dileepan, K.N., Kennedy, J. FEBS Lett. (1983) [Pubmed]
  12. Localization of dihydroorotate oxidase in myocardium and kidney cortex of the rat. An electron microscopic study using the cerium technique. Angermüller, S., Löffler, M. Histochem. Cell Biol. (1995) [Pubmed]
  13. Regulation of alloreactivity in the popliteal lymph node assay by the new immunosuppressants: malononitrilamides. Schorlemmer, H.U., Ruuth, E., Kurrle, R. Transpl. Int. (1998) [Pubmed]
  14. Dihydroorotat-ubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides. Löffler, M., Jöckel, J., Schuster, G., Becker, C. Mol. Cell. Biochem. (1997) [Pubmed]
  15. Neuromelanogenic and cytotoxic properties of canine brainstem peroxidase. Grisham, M.B., Perez, V.J., Everse, J. J. Neurochem. (1987) [Pubmed]
  16. Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat. Elliott, W.L., Sawick, D.P., DeFrees, S.A., Heinstein, P.F., Cassady, J.M., Morré, D.J. Biochim. Biophys. Acta (1984) [Pubmed]
  17. Molecular cloning and sequence analyses of rat liver dihydroorotate dehydrogenase. Rotgeri, A., Löffler, M. Adv. Exp. Med. Biol. (1994) [Pubmed]
  18. Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis. Kim, K.S., Choi, Y.H., Kim, K.H., Lee, Y.C., Kim, C.H., Moon, S.H., Kang, S.G., Park, Y.G. Int. Immunopharmacol. (2004) [Pubmed]
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