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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers.

Four primary cancers found at autopsy of a patient who received the thorium-based contrast agent Thorotrast 50 years ago and who was healthy up until a few months before his death from liver failure were analyzed for p53 mutations. The data suggest that the chronic alpha-irradiation may be a large causative factor. Multiple mutations were found in all the cancer tissues: two foci of a cholangiocellular carcinoma, a tubular adenocarcinoma of the stomach, a squamous cell carcinoma of the lung, and an adenocarcinoma of Vater's ampulla. The total number of point mutations detected were 13. Moreover, homozygous aberrations were detected in a large area of normal small intestine and noncancer liver tissues suggesting that nontumor cells which harbored p53 abnormalities gained a survival advantage and clonally expanded.[1]

References

  1. Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers. Iwamoto, K.S., Mizuno, T., Kurata, A., Masuzawa, M., Mori, T., Seyama, T. Hum. Pathol. (1998) [Pubmed]
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