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MeSH Review

Ampulla of Vater

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Disease relevance of Ampulla of Vater


High impact information on Ampulla of Vater


Chemical compound and disease context of Ampulla of Vater


Biological context of Ampulla of Vater

  • For the purpose of determining the prognostic significance of HER2/neu oncogene in pancreatic and ampullary cancers, 21 pancreatic cancers of ductal origin and six cancers of the ampulla of Vater were studied immunohistochemically using the monoclonal antibody (MAb) CB11, specifically reactive with HER2/neu product [14].
  • Mutational analysis of exon3 in CTNNB-1, which encodes the serine/threonine residues for GSK-3beta phosphorylation sites, was performed on 21 cases of carcinoma of the ampulla of Vater, by means of polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) followed by nucleotide sequencing [15].

Anatomical context of Ampulla of Vater


Associations of Ampulla of Vater with chemical compounds


Gene context of Ampulla of Vater

  • TFF3 was expressed in the ampulla of Vater. mRNA expression of TFF1 was detected in only approximately 25% of the investigated samples [24].
  • Proliferating cell nuclear antigen, p53, and c-erbB-2 expression in relation to clinicopathological variables and prognosis in cancer of the ampulla of Vater [25].
  • In contrast, the proportion of down-regulated p16 expression was the least among the patients in the region of the ampulla of Vater with better prognosis, and we showed that the prognosis of patients with down-regulated expression of p16 was the poorest in terms of the cancer location where it is limited to the region of ampulla of Vater [26].
  • Fourty-six patients with ampulla of Vater cancer were enrolled and their COX-2 expression and clinicopathologic features were analyzed [27].
  • A higher percentage of cases with overexpression of c-erbB-3 in pancreatic head carcinoma and overexpression of c-erbB-2 in carcinoma of the ampulla of Vater was found in Ki-67 antigen-positive cases [28].

Analytical, diagnostic and therapeutic context of Ampulla of Vater


  1. Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. Hansel, D.E., Maitra, A., Lin, J.W., Goggins, M., Argani, P., Yeo, C.J., Piantadosi, S., Leach, S.D., Biankin, A.V. J. Clin. Oncol. (2005) [Pubmed]
  2. Mucin-producing neoplasms of the pancreas. Intraductal papillary and mucinous cystic neoplasms. Shyr, Y.M., Su, C.H., Tsay, S.H., Lui, W.Y. Ann. Surg. (1996) [Pubmed]
  3. The diagnostic value of a hepatoma-specific band of serum gamma-glutamyl transferase. Xu, K.C., Meng, X.Y., Shi, Y.C., Ge, Z.J., Ye, L., Yu, Z.J., Yang, D.M. Int. J. Cancer (1985) [Pubmed]
  4. Carcinoma of the ampulla of Vater associated with or without adenoma: a clinicopathologic analysis of 198 cases with reference to p53 and Ki-67 immunohistochemical expressions. Takashima, M., Ueki, T., Nagai, E., Yao, T., Yamaguchi, K., Tanaka, M., Tsuneyoshi, M. Mod. Pathol. (2000) [Pubmed]
  5. Ampullary adenocarcinoma in neurofibromatosis type 1. Case report and literature review. Costi, R., Caruana, P., Sarli, L., Violi, V., Roncoroni, L., Bordi, C. Mod. Pathol. (2001) [Pubmed]
  6. Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Fukuda, A., Kawaguchi, Y., Furuyama, K., Kodama, S., Kuhara, T., Horiguchi, M., Koizumi, M., Fujimoto, K., Doi, R., Wright, C.V., Chiba, T. Gastroenterology (2006) [Pubmed]
  7. Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations. Scarpa, A., Capelli, P., Zamboni, G., Oda, T., Mukai, K., Bonetti, F., Martignoni, G., Iacono, C., Serio, G., Hirohashi, S. Am. J. Pathol. (1993) [Pubmed]
  8. Prognostic value of MIB-1 index and DNA ploidy in resectable ampulla of Vater carcinoma. Shyr, Y.M., Su, C.H., Wu, L.H., Li, A.F., Chiu, J.H., Wu, C.W., Lui, W.Y. Ann. Surg. (1999) [Pubmed]
  9. Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. Santini, D., Vincenzi, B., Tonini, G., Scarpa, S., Vasaturo, F., Malacrino, C., Vecchio, F., Borzomati, D., Valeri, S., Coppola, R., Magistrelli, P., Nuzzo, G., Picciocchi, A. Clin. Cancer Res. (2005) [Pubmed]
  10. Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. Nakazawa, K., Dobashi, Y., Suzuki, S., Fujii, H., Takeda, Y., Ooi, A. J. Pathol. (2005) [Pubmed]
  11. Pancreatic pseudocyst: heparin-induced haemorrhage through the ampulla of Vater. Hong, D., Gately, J.F., Heggtveit, H.A. Journal of the Royal College of Surgeons of Edinburgh. (1999) [Pubmed]
  12. Carcinoid of the ampulla of Vater--report of two cases. Mavroudis, N., Rafailidis, S., Symeonidis, N., Aimoniotou, E., Antonopoulos, V., Evgenidis, N., Venizelos, L., Sakadamis, A. Acta chirurgica Belgica. (2005) [Pubmed]
  13. DNA ploidy and cell-cycle analysis in pancreatic and ampullary carcinoma: flow cytometric study of formalin-fixed paraffin-embedded tissue. Baisch, H., Klöppel, G., Reinke, B. Virchows Archiv. A, Pathological anatomy and histopathology. (1990) [Pubmed]
  14. Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival. Lei, S., Appert, H.E., Nakata, B., Domenico, D.R., Kim, K., Howard, J.M. Int. J. Pancreatol. (1995) [Pubmed]
  15. beta-Catenin alteration in cancer of the ampulla of Vater. Kawakami, M., Kimura, Y., Furuhata, T., Zenbutsu, H., Yanai, Y., Mukaiya, M., Satoh, Y., Murata, S., Hirata, K. J. Exp. Clin. Cancer Res. (2002) [Pubmed]
  16. Carcinoembryonic antigen (CEA) in benign and malignant epithelium of the gall bladder, extrahepatic bile ducts, and ampulla of Vater. Maxwell, P., Davis, R.I., Sloan, J.M. J. Pathol. (1993) [Pubmed]
  17. CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. Hou, L., Xu, J., Gao, Y.T., Rashid, A., Zheng, S.L., Sakoda, L.C., Shen, M.C., Wang, B.S., Deng, J., Han, T.Q., Zhang, B.H., Meyers, D.A., Fraumeni, J.F., Hsing, A.W. Int. J. Cancer (2006) [Pubmed]
  18. Clinical significance of immunohistochemically detectable lymph node metastasis in adenocarcinoma of the ampulla of Vater. Mizuno, T., Ishizaki, Y., Ogura, K., Yoshimoto, J., Kawasaki, S. The British journal of surgery. (2006) [Pubmed]
  19. Prognostic value of mucins in the classification of ampullary carcinomas. Paulsen, F.P., Varoga, D., Paulsen, A.R., Corfield, A., Tsokos, M. Hum. Pathol. (2006) [Pubmed]
  20. Prostaglandin E2 derived from phosphatidylinositol breakdown in the exocrine pancreas facilitates secretion by an action on the ducts. Marshall, P.J., Dixon, J.F., Hokin, L.E. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  21. Patency of the human accessory pancreatic duct as determined by dye-injection endoscopic retrograde pancreatography. Kamisawa, T., Tabata, I., Tajima, T., Tsushima, K., Yoshida, Y. Digestion (1997) [Pubmed]
  22. Metformin in the digestive tract. Vidon, N., Chaussade, S., Noel, M., Franchisseur, C., Huchet, B., Bernier, J.J. Diabetes Res. Clin. Pract. (1988) [Pubmed]
  23. Combination chemotherapy for metastatic carcinoma of the ampulla of Vater--report of three cases. Bukowski, R.M., Hermann, R.E., Theodors, A. Journal of surgical oncology. (1984) [Pubmed]
  24. Trefoil factor family (TFF) peptides of normal human Vater's ampulla. Paulsen, F., Varoga, D., Paulsen, A., Tsokos, M. Cell Tissue Res. (2005) [Pubmed]
  25. Proliferating cell nuclear antigen, p53, and c-erbB-2 expression in relation to clinicopathological variables and prognosis in cancer of the ampulla of Vater. Ajiki, T., Kamigaki, T., Hasegawa, Y., Fujino, Y., Suzuki, Y., Takeyama, Y., Ku, Y., Kuroda, Y. Hepatogastroenterology (2001) [Pubmed]
  26. Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomas. Ichikawa, K., Imura, J., Kawamata, H., Takeda, J., Fujimori, T. Int. J. Oncol. (2002) [Pubmed]
  27. Expression of cyclooxygenase-2 and its correlation with clinicopathologic factors of ampulla of vater cancer. Kim, H.J., Sohn, T.S., Lee, K.T., Lee, J.K., Paik, S.W., Rhee, J.C. J. Korean Med. Sci. (2003) [Pubmed]
  28. Overexpression of different members of the type 1 growth factor receptor family and their association with cell proliferation in periampullary carcinoma. Vaidya, P., Kawarada, Y., Higashiguchi, T., Yoshida, T., Sakakura, T., Yatani, R. J. Pathol. (1996) [Pubmed]
  29. Bronchial carcinoid with fibrillary inclusions related to cytokeratins: an immunohistochemical and ultrastructural study with subsequent investigation of 12 foregut APUDomas. Berger, G., Berger, F., Bejui, F., Bouvier, R., Rochet, M., Feroldi, J. Histopathology (1984) [Pubmed]
  30. Polypoid tumors of the major duodenal papilla: preoperative staging with intraductal US, EUS, and CT--a prospective, histopathologically controlled study. Menzel, J., Hoepffner, N., Sulkowski, U., Reimer, P., Heinecke, A., Poremba, C., Domschke, W. Gastrointest. Endosc. (1999) [Pubmed]
  31. Buscopan or glucagon for endoscopic cannulation of ampulla of vater? Hannigan, B.F., Axon, A.T., Avery, S., Thompson, R.P. Journal of the Royal Society of Medicine. (1982) [Pubmed]
  32. Percutaneous placement of metallic stents in the management of malignant biliary obstruction. Chiou, Y.Y., Tseng, H.S., Chiang, J.H., Hwang, J.I., Chou, Y.H., Chang, C.Y. J. Formos. Med. Assoc. (2005) [Pubmed]
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