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MeSH Review

Liver Failure

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Disease relevance of Liver Failure


Psychiatry related information on Liver Failure


High impact information on Liver Failure


Chemical compound and disease context of Liver Failure

  • Renal glutamine uptake and subsequent urinary ammonia excretion could be an important alternative pathway of ammonia disposal from the body during liver failure (diminished urea synthesis), but this pathway has received little attention [14].
  • Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor [15].
  • Six months later, she experienced a rapidly progressive hepatic failure manifested by elevation of serum bilirubin level, prolongation of prothrombin time, and mild to modest increase of serum aminotransferase levels [16].
  • To study in detail the role of the liver in GABA metabolism, uptake and catabolism of GABA by isolated perfused liver from normal rats and rats with galactosamine- or carbon tetrachloride-induced liver failure were measured [17].
  • Our experience shows that fibrosing cholestatic hepatitis and liver failure caused by HBV infection can be successfully treated with lamivudine [18].

Biological context of Liver Failure


Anatomical context of Liver Failure


Gene context of Liver Failure

  • The apoptotic-inducing capacity of naturally processed sFasL was reduced by >1,000-fold compared with membrane-bound FasL, and injection of high doses of recombinant sFasL in mice did not induce liver failure [28].
  • The aim of this study was to investigate whether endogenously formed TNF contributes to liver failure caused by hepatotoxins [29].
  • Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy [30].
  • Transferrin saturation above 75% was related to iron overload in GH and to liver failure in alcoholic cirrhosis [31].
  • Wilson disease is an autosomal recessive copper transport disorder resulting from defective biliary excretion of copper and subsequent hepatic copper accumulation and liver failure if not treated [32].

Analytical, diagnostic and therapeutic context of Liver Failure


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  3. Potentiation by granulocyte macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice. Tiegs, G., Barsig, J., Matiba, B., Uhlig, S., Wendel, A. J. Clin. Invest. (1994) [Pubmed]
  4. A novel mutation in medium chain acyl-CoA dehydrogenase causes sudden neonatal death. Brackett, J.C., Sims, H.F., Steiner, R.D., Nunge, M., Zimmerman, E.M., deMartinville, B., Rinaldo, P., Slaugh, R., Strauss, A.W. J. Clin. Invest. (1994) [Pubmed]
  5. Diurnal fluctuations of arterial ketone body ratio in normal subjects and patients with liver dysfunction. Iwata, S., Ozawa, K., Shimahara, Y., Mori, K., Kobayashi, N., Kumada, K., Yamaoka, Y. Gastroenterology (1991) [Pubmed]
  6. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Maitre, M. Prog. Neurobiol. (1997) [Pubmed]
  7. Feeding behavior and ambulatory activity in rats with D-galactosamine-induced hepatic failure. Shimomura, Y., Saito, S., Nagamine, T., Shimizu, H., Takahashi, M., Uehara, Y., Sato, N., Negishi, M., Yamada, S., Kobayashi, I. Physiol. Behav. (1992) [Pubmed]
  8. Analysis of factors responsible for continuing mortality after paracetamol overdose. Read, R.B., Tredger, J.M., Williams, R. Human toxicology. (1986) [Pubmed]
  9. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. McWhir, J., Selfridge, J., Harrison, D.J., Squires, S., Melton, D.W. Nat. Genet. (1993) [Pubmed]
  10. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. Harrison, P.M., Wendon, J.A., Gimson, A.E., Alexander, G.J., Williams, R. N. Engl. J. Med. (1991) [Pubmed]
  11. Hepatic failure from valproic acid. Partin, J.S., McAdams, A.J., Suchy, F.J., Balistreri, W.F. N. Engl. J. Med. (1979) [Pubmed]
  12. Interleukin-15 protects from lethal apoptosis in vivo. Bulfone-Paus, S., Ungureanu, D., Pohl, T., Lindner, G., Paus, R., Rückert, R., Krause, H., Kunzendorf, U. Nat. Med. (1997) [Pubmed]
  13. Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. Zuckerbraun, B.S., Billiar, T.R., Otterbein, S.L., Kim, P.K., Liu, F., Choi, A.M., Bach, F.H., Otterbein, L.E. J. Exp. Med. (2003) [Pubmed]
  14. Renal ammonia and glutamine metabolism during liver insufficiency-induced hyperammonemia in the rat. Dejong, C.H., Deutz, N.E., Soeters, P.B. J. Clin. Invest. (1993) [Pubmed]
  15. Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor. Weisiger, R.A., Ma, W.L. J. Clin. Invest. (1987) [Pubmed]
  16. Fibrosing cholestatic hepatitis in a hepatitis B surface antigen carrier after renal transplantation. Chen, C.H., Chen, P.J., Chu, J.S., Yeh, K.H., Lai, M.Y., Chen, D.S. Gastroenterology (1994) [Pubmed]
  17. Uptake and catabolism of gamma-aminobutyric acid by the isolated perfused rat liver. Ferenci, P., Stehle, T., Ebner, J., Schmid, R., Häussinger, D. Gastroenterology (1988) [Pubmed]
  18. Treatment of fibrosing cholestatic hepatitis with lamivudine. Chan, T.M., Wu, P.C., Li, F.K., Lai, C.L., Cheng, I.K., Lai, K.N. Gastroenterology (1998) [Pubmed]
  19. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Küsters, S., Gantner, F., Künstle, G., Tiegs, G. Gastroenterology (1996) [Pubmed]
  20. Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality. Wullaert, A., Wielockx, B., Van Huffel, S., Bogaert, V., De Geest, B., Papeleu, P., Schotte, P., El Bakkouri, K., Heyninck, K., Libert, C., Beyaert, R. Hepatology (2005) [Pubmed]
  21. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Kon, K., Kim, J.S., Jaeschke, H., Lemasters, J.J. Hepatology (2004) [Pubmed]
  22. Effect of Lactobacillus supplementation with and without arginine on liver damage and bacterial translocation in an acute liver injury model in the rat. Adawi, D., Kasravi, F.B., Molin, G., Jeppsson, B. Hepatology (1997) [Pubmed]
  23. Loss of p27(Kip1) enhances the transplantation efficiency of hepatocytes transferred into diseased livers. Karnezis, A.N., Dorokhov, M., Grompe, M., Zhu, L. J. Clin. Invest. (2001) [Pubmed]
  24. Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors. Kubo, S., Sun, M., Miyahara, M., Umeyama, K., Urakami, K., Yamamoto, T., Jakobs, C., Matsuda, I., Endo, F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  25. Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter: a comparison of two rodent models of fulminant liver failure. Swain, M.S., Bergeron, M., Audet, R., Blei, A.T., Butterworth, R.F. Hepatology (1992) [Pubmed]
  26. Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Leifeld, L., Fink, K., Debska, G., Fielenbach, M., Schmitz, V., Sauerbruch, T., Spengler, U. Am. J. Pathol. (2006) [Pubmed]
  27. Hepatic vein reconstruction for resection of hepatic tumors. Hemming, A.W., Reed, A.I., Langham, M.R., Fujita, S., van der Werf, W.J., Howard, R.J. Ann. Surg. (2002) [Pubmed]
  28. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. Schneider, P., Holler, N., Bodmer, J.L., Hahne, M., Frei, K., Fontana, A., Tschopp, J. J. Exp. Med. (1998) [Pubmed]
  29. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Leist, M., Gantner, F., Naumann, H., Bluethmann, H., Vogt, K., Brigelius-Flohé, R., Nicotera, P., Volk, H.D., Wendel, A. Gastroenterology (1997) [Pubmed]
  30. Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy. Valnot, I., Osmond, S., Gigarel, N., Mehaye, B., Amiel, J., Cormier-Daire, V., Munnich, A., Bonnefont, J.P., Rustin, P., Rötig, A. Am. J. Hum. Genet. (2000) [Pubmed]
  31. Redox active plasma iron in C282Y/C282Y hemochromatosis. Le Lan, C., Loréal, O., Cohen, T., Ropert, M., Glickstein, H., Lainé, F., Pouchard, M., Deugnier, Y., Le Treut, A., Breuer, W., Cabantchik, Z.I., Brissot, P. Blood (2005) [Pubmed]
  32. Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copper ATPase. La Fontaine , S., Theophilos, M.B., Firth, S.D., Gould, R., Parton, R.G., Mercer, J.F. Hum. Mol. Genet. (2001) [Pubmed]
  33. Troglitazone-induced hepatic failure leading to liver transplantation. A case report. Neuschwander-Tetri, B.A., Isley, W.L., Oki, J.C., Ramrakhiani, S., Quiason, S.G., Phillips, N.J., Brunt, E.M. Ann. Intern. Med. (1998) [Pubmed]
  34. Human hepatocyte growth factor in bile: an indicator of posthepatectomy liver function in patients with biliary tract carcinoma. Takeuchi, E., Nimura, Y., Nagino, M., Kurumiya, Y., Maeda, A., Kamiya, J., Kondo, S., Kanai, M., Miyachi, M., Uesaka, K., Yoshida, S. Hepatology (1997) [Pubmed]
  35. The fate of intravenously injected endotoxin in normal rats and in rats with liver failure. Nakao, A., Taki, S., Yasui, M., Kimura, Y., Nonami, T., Harada, A., Takagi, H. Hepatology (1994) [Pubmed]
  36. Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts. Erceg, S., Monfort, P., Hernández-Viadel, M., Rodrigo, R., Montoliu, C., Felipo, V. Hepatology (2005) [Pubmed]
  37. Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Aithal, G.P., Ramsay, L., Daly, A.K., Sonchit, N., Leathart, J.B., Alexander, G., Kenna, J.G., Caldwell, J., Day, C.P. Hepatology (2004) [Pubmed]
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