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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity.

We examined midkine ( MK) expression in the rat heart upon experimental myocardial infarction. Immunohistochemical staining revealed, 6 hours after ligation of the left anterior descending coronary artery, strong MK immunoreactivity in myocytes and endothelial cells of a non-infarcted cardiac region. The myocytes of the infarcted cardiac region destined for death showed only a little immunoreactivity. Northern blot analysis suggested that the increased immunoreactivity was due to increased MK synthesis. The induced MK expression is likely to mimic the expression during embryogenesis: MK was strong lye-expressed in the myocytes of embryonic heart, and the expression decreased during embryogenesis.[1]

References

  1. Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity. Obama, H., Biro, S., Tashiro, T., Tsutsui, J., Ozawa, M., Yoshida, H., Tanaka, H., Muramatsu, T. Anticancer Res. (1998) [Pubmed]
 
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