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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.

In humans, interferon gamma ( IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion.[1]

References

  1. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Altare, F., Durandy, A., Lammas, D., Emile, J.F., Lamhamedi, S., Le Deist, F., Drysdale, P., Jouanguy, E., Döffinger, R., Bernaudin, F., Jeppsson, O., Gollob, J.A., Meinl, E., Segal, A.W., Fischer, A., Kumararatne, D., Casanova, J.L. Science (1998) [Pubmed]
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