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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pyridoxine-responsive PH1: treatment.

Owing to the rarity of PH, the efficacy of pyridoxine therapy has only been tested in very small series of patients. From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized in 20% of patients and somewhat reduced-but not to normal level-in the remaining 30%. In a few aneodotical cases pyridoxine administration was reported to improve kidney function in patients with renal failure secondary to hyperoxaluria. It is reminded that megadoses of pyridoxine (0.5 to 6 g daily) may induce severe sensory neuropathy.[1]


  1. Pyridoxine-responsive PH1: treatment. Toussaint, C. J. Nephrol. (1998) [Pubmed]
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