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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

The leukocyte-specific adapter molecule SLP-76 ( Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.[1]


  1. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Clements, J.L., Yang, B., Ross-Barta, S.E., Eliason, S.L., Hrstka, R.F., Williamson, R.A., Koretzky, G.A. Science (1998) [Pubmed]
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