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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cloning of the Arabidopsis ent-kaurene oxidase gene GA3.

The ga3 mutant of Arabidopsis is a gibberellin-responsive dwarf. We present data showing that the ga3-1 mutant is deficient in ent-kaurene oxidase activity, the first cytochrome P450-mediated step in the gibberellin biosynthetic pathway. By using a combination of conventional map-based cloning and random sequencing we identified a putative cytochrome P450 gene mapping to the same location as GA3. Relative to the progenitor line, two ga3 mutant alleles contained single base changes generating in-frame stop codons in the predicted amino acid sequence of the P450. A genomic clone spanning the P450 locus complemented the ga3-2 mutant. The deduced GA3 protein defines an additional class of cytochrome P450 enzymes. The GA3 gene was expressed in all tissues examined, RNA abundance being highest in inflorescence tissue.[1]


  1. Cloning of the Arabidopsis ent-kaurene oxidase gene GA3. Helliwell, C.A., Sheldon, C.C., Olive, M.R., Walker, A.R., Zeevaart, J.A., Peacock, W.J., Dennis, E.S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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