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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B.

Human CD1 is a family of nonpolymorphic major histocompatibility complex class I-like molecules capable of presenting mycobacterial lipids, including lipoarabinomannan (LAM), to double-negative (DN; CD4(-) CD8(-)) as well as CD8(+) T cells. Structural similarities between LAM and the capsular polysaccharides of gram-negative bacteria led us to consider the latter as candidate CD1 ligands. We derived two CD1-restricted DN T-cell populations which proliferated to Haemophilus influenzae type b (Hib) antigen. One T-cell population also proliferated to proteinase K-treated Hib antigen, suggesting that it recognized a nonpeptide. Our work thus expands the universe of T cell antigens to include nonpeptides distinct from mycobacterial lipids and suggests a potential role for CD1-restricted T cells in immunity to Hib.[1]

References

  1. CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B. Fairhurst, R.M., Wang, C.X., Sieling, P.A., Modlin, R.L., Braun, J. Infect. Immun. (1998) [Pubmed]
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