Gene Review:
ERVK-6 - endogenous retrovirus group K, member 6
Homo sapiens
Synonyms:
ERVK6, HERV-K(C7), HERV-K(HML-2.HOM), HERV-K108, K-Rev, ...
Dri,
Gasparini,
Menegazzi,
Cramer,
Albéri,
Presani,
Garbisa,
Patriarca,
Tönjes,
Limbach,
Löwer,
Kurth,
Steinhoff,
Buddenkotte,
Shpacovitch,
Rattenholl,
Moormann,
Vergnolle,
Luger,
Hollenberg,
Cao,
Rehemtulla,
Pavlaki,
Kozarekar,
Chiarelli,
- Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7. Reus, K., Mayer, J., Sauter, M., Scherer, D., Müller-Lantzsch, N., Meese, E. Genomics (2001)
- An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Yang, J., Bogerd, H.P., Peng, S., Wiegand, H., Truant, R., Cullen, B.R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The 5' RNA terminus of spleen necrosis virus contains a novel posttranscriptional control element that facilitates human immunodeficiency virus Rev/RRE-independent Gag production. Butsch, M., Hull, S., Wang, Y., Roberts, T.M., Boris-Lawrie, K. J. Virol. (1999)
- Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K. Bogerd, H.P., Wiegand, H.L., Yang, J., Cullen, B.R. J. Virol. (2000)
- Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K. Löwer, R., Tönjes, R.R., Korbmacher, C., Kurth, R., Löwer, J. J. Virol. (1995)
- Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. Medori, R., Tritschler, H.J., LeBlanc, A., Villare, F., Manetto, V., Chen, H.Y., Xue, R., Leal, S., Montagna, P., Cortelli, P. N. Engl. J. Med. (1992)
- In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase. Howlett, D.R., Simmons, D.L., Dingwall, C., Christie, G. Trends Neurosci. (2000)
- Incidence and disease associations of a proteinase 3-antineutrophil cytoplasmic antibody idiotype (5/7 Id) whose antiidiotype inhibits proteinase 3-antineutrophil cytoplasmic antibody antigen binding activity. Strunz, H.P., Csernok, E., Gross, W.L. Arthritis Rheum. (1997)
- Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state. Caughey, B., Kocisko, D.A., Raymond, G.J., Lansbury, P.T. Chem. Biol. (1995)
- A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin. Yasuda, Y., Kohmura, K., Kadowaki, T., Tsukuba, T., Yamamoto, K. Biol. Chem. (2005)
- The retroviral enzymes. Katz, R.A., Skalka, A.M. Annu. Rev. Biochem. (1994)
- Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Roosterman, D., Goerge, T., Schneider, S.W., Bunnett, N.W., Steinhoff, M. Physiol. Rev. (2006)
- ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane. Lévy, F., Gabathuler, R., Larsson, R., Kvist, S. Cell (1991)
- Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade. Mignatti, P., Robbins, E., Rifkin, D.B. Cell (1986)
- A protease-resistant protein is a structural component of the scrapie prion. McKinley, M.P., Bolton, D.C., Prusiner, S.B. Cell (1983)
- The effect of cerulenin on the synthesis of the precursor gag polyprotein in defective murine leukemia and sarcoma virus producing cell lines. Ikuta, K., Coward, J., Luftig, R.B. Virology (1986)
- Effect of a human immunodeficiency virus protease inhibitor on human monocyte function. Bugelski, P.J., Kaplan, J.M., Hart, T.K., Miller, J., Laydon, J.T., Lee, J.C., Dreyer, G.B., Kirsh, R. AIDS Res. Hum. Retroviruses (1992)
- Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor. Katoh, I., Yasunaga, T., Ikawa, Y., Yoshinaka, Y. Nature (1987)
- Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Steinhoff, M., Vergnolle, N., Young, S.H., Tognetto, M., Amadesi, S., Ennes, H.S., Trevisani, M., Hollenberg, M.D., Wallace, J.L., Caughey, G.H., Mitchell, S.E., Williams, L.M., Geppetti, P., Mayer, E.A., Bunnett, N.W. Nat. Med. (2000)
- Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein. Boese, A., Sauter, M., Galli, U., Best, B., Herbst, H., Mayer, J., Kremmer, E., Roemer, K., Mueller-Lantzsch, N. Oncogene (2000)
- cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K. Magin, C., Löwer, R., Löwer, J. J. Virol. (1999)
- Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K. Tönjes, R.R., Czauderna, F., Kurth, R. J. Virol. (1999)
- Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins. McGuire, T.C., Tumas, D.B., Byrne, K.M., Hines, M.T., Leib, S.R., Brassfield, A.L., O'Rourke, K.I., Perryman, L.E. J. Virol. (1994)
- Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor. Chapman, H.A., Vavrin, Z., Hibbs, J.B. Cell (1982)
- EGTA and proteinase reversal of cellular aggregation of activated lymphocytes. Neely, A.N., Sitzmann, J.V., Kersey, J.H. Nature (1976)
- Ultrastructural localization of the RNA of immunodeficiency viruses using electron microscopy in situ hybridization and in vitroinfected lymphocytes. Cantó-Nogués, C., Hockley, D., Grief, C., Ranjbar, S., Bootman, J., Almond, N., Herrera, I. Micron (2001)
- Purification and structural studies of a major scrapie prion protein. Prusiner, S.B., Groth, D.F., Bolton, D.C., Kent, S.B., Hood, L.E. Cell (1984)
- Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. Pereira, P.J., Bergner, A., Macedo-Ribeiro, S., Huber, R., Matschiner, G., Fritz, H., Sommerhoff, C.P., Bode, W. Nature (1998)
- Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor. Björck, L., Akesson, P., Bohus, M., Trojnar, J., Abrahamson, M., Olafsson, I., Grubb, A. Nature (1989)
- The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi. Wooten, R.M., Morrison, T.B., Weis, J.H., Wright, S.D., Thieringer, R., Weis, J.J. J. Immunol. (1998)
- Pregnancy zone protein, a proteinase-binding macroglobulin. Interactions with proteinases and methylamine. Christensen, U., Simonsen, M., Harrit, N., Sottrup-Jensen, L. Biochemistry (1989)
- Involvement of a region near valine-69 of tissue inhibitor of metalloproteinases (TIMP)-1 in the interaction with matrix metalloproteinase 3 (stromelysin 1). Nagase, H., Suzuki, K., Cawston, T.E., Brew, K. Biochem. J. (1997)
- Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics. Borth, W. FASEB J. (1992)
- Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation. Jairajpuri, M.A., Lu, A., Desai, U., Olson, S.T., Bjork, I., Bock, S.C. J. Biol. Chem. (2003)
- A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Miyazaki, K., Hasegawa, M., Funahashi, K., Umeda, M. Nature (1993)
- Furin directly cleaves proMMP-2 in the trans-Golgi network resulting in a nonfunctioning proteinase. Cao, J., Rehemtulla, A., Pavlaki, M., Kozarekar, P., Chiarelli, C. J. Biol. Chem. (2005)
- Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology. Durham, S.K., Kiefer, M.C., Riggs, B.L., Conover, C.A. J. Bone Miner. Res. (1994)
- Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. Tagliavini, F., Prelli, F., Ghiso, J., Bugiani, O., Serban, D., Prusiner, S.B., Farlow, M.R., Ghetti, B., Frangione, B. EMBO J. (1991)
- Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13. Pimanda, J.E., Maekawa, A., Wind, T., Paxton, J., Chesterman, C.N., Hogg, P.J. Blood (2004)
- Proteasomal RNase activity in human epidermis. Horikoshi, T., Page, J., Lei, G., Brysk, H., Arany, I., Tyring, S.K., Brysk, M.M. In Vivo (1998)
- Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells. Tönjes, R.R., Limbach, C., Löwer, R., Kurth, R. J. Virol. (1997)
- Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Ma, L., Perini, R., McKnight, W., Dicay, M., Klein, A., Hollenberg, M.D., Wallace, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- TNF-Induced shedding of TNF receptors in human polymorphonuclear leukocytes: role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase. Dri, P., Gasparini, C., Menegazzi, R., Cramer, R., Albéri, L., Presani, G., Garbisa, S., Patriarca, P. J. Immunol. (2000)
- The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3. Will, H., Atkinson, S.J., Butler, G.S., Smith, B., Murphy, G. J. Biol. Chem. (1996)
- Prodomain processing of Asp1 (BACE2) is autocatalytic. Hussain, I., Christie, G., Schneider, K., Moore, S., Dingwall, C. J. Biol. Chem. (2001)
- Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. Mueller, C.G., Rissoan, M.C., Salinas, B., Ait-Yahia, S., Ravel, O., Bridon, J.M., Briere, F., Lebecque, S., Liu, Y.J. J. Exp. Med. (1997)
- Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: transdominant inhibition by matrix mutations. Kiernan, R.E., Freed, E.O. J. Virol. (1998)
- A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy. Weber, J., Rangel, H.R., Chakraborty, B., Tadele, M., Martinez, M.A., Martinez-Picado, J., Marotta, M.L., Mirza, M., Ruiz, L., Clotet, B., Wrin, T., Petropoulos, C.J., Quiñones-Mateu, M.E. J. Gen. Virol. (2003)
- Human endogenous retrovirus HERV-K(HML-2) Rec expression and transcriptional activities in normal and rheumatoid arthritis synovia. Ehlhardt, S., Seifert, M., Schneider, J., Ojak, A., Zang, K.D., Mehraein, Y. J. Rheumatol. (2006)
- Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Steinhoff, M., Buddenkotte, J., Shpacovitch, V., Rattenholl, A., Moormann, C., Vergnolle, N., Luger, T.A., Hollenberg, M.D. Endocr. Rev. (2005)
- Hereditary tyrosinemia. Formation of succinylacetone-amino acid adducts. Manabe, S., Sassa, S., Kappas, A. J. Exp. Med. (1985)