Yeast coactivator MBF1 mediates GCN4-dependent transcriptional activation.
Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1 ( MBF1) was originally identified as a bridging molecule that connects the Drosophila nuclear receptor FTZ-F1 and TATA-binding protein ( TBP). The MBF1 sequence is highly conserved across species from Saccharomyces cerevisiae to human. Here we provide evidence acquired in vitro and in vivo that yeast MBF1 mediates GCN4-dependent transcriptional activation by bridging the DNA- binding region of GCN4 and TBP. These findings indicate that the coactivator MBF1 functions by recruiting TBP to promoters where DNA-binding regulators are bound.[1]References
- Yeast coactivator MBF1 mediates GCN4-dependent transcriptional activation. Takemaru, K., Harashima, S., Ueda, H., Hirose, S. Mol. Cell. Biol. (1998) [Pubmed]
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