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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas ( CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas- FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.[1]

References

  1. Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis. Bennett, M., Macdonald, K., Chan, S.W., Luzio, J.P., Simari, R., Weissberg, P. Science (1998) [Pubmed]
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