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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Encouraging initial response of restless legs syndrome to pramipexole.

Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.[1]


  1. Encouraging initial response of restless legs syndrome to pramipexole. Becker, P.M., Ondo, W., Sharon, D. Neurology (1998) [Pubmed]
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