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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

B-cell development: a comparison between mouse and man.

A common variable immunodeficiency (CVID) patient, who carries mutations on both alleles of the gene encoding the surrogate light chain component lambda 5/14.1, shows a similar phenotype of B-cell deficiency as the lambda 5-deficient mutant mouse. As discussed here by Paolo Ghia and colleagues, this points to a remarkably similar developmental pathway of B cells in humans and mice.[1]


  1. B-cell development: a comparison between mouse and man. Ghia, P., ten Boekel, E., Rolink, A.G., Melchers, F. Immunol. Today (1998) [Pubmed]
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