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MeSH Review

Common Variable Immunodeficiency

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Disease relevance of Common Variable Immunodeficiency


High impact information on Common Variable Immunodeficiency


Chemical compound and disease context of Common Variable Immunodeficiency


Biological context of Common Variable Immunodeficiency


Anatomical context of Common Variable Immunodeficiency


Gene context of Common Variable Immunodeficiency


Analytical, diagnostic and therapeutic context of Common Variable Immunodeficiency


  1. Relative increase of T cells expressing the gamma/delta rather than the alpha/beta receptor in ataxia-telangiectasia. Carbonari, M., Cherchi, M., Paganelli, R., Giannini, G., Galli, E., Gaetano, C., Papetti, C., Fiorilli, M. N. Engl. J. Med. (1990) [Pubmed]
  2. Genetic basis of abnormal B cell development. Conley, M.E., Cooper, M.D. Curr. Opin. Immunol. (1998) [Pubmed]
  3. Common variable immunodeficiency, Hodgkin's disease, and other malignancies in a Newfoundland family. Buehler, S.K., Firme, F., Fodor, G., Fraser, G.R., Marshall, W.H., Vaze, P. Lancet (1975) [Pubmed]
  4. Gastrointestinal regulatory peptide storage granule abnormalities in jejunal mucosal diseases. Dawson, J., Bryant, M.G., Bloom, S.R., Peters, T.J. Gut (1984) [Pubmed]
  5. Viruses and bacteria in bronchial samples from patients with primary hypogammaglobulinemia. Kainulainen, L., Nikoskelainen, J., Vuorinen, T., Tevola, K., Liippo, K., Ruuskanen, O. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  6. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Salzer, U., Chapel, H.M., Webster, A.D., Pan-Hammarström, Q., Schmitt-Graeff, A., Schlesier, M., Peter, H.H., Rockstroh, J.K., Schneider, P., Schäffer, A.A., Hammarström, L., Grimbacher, B. Nat. Genet. (2005) [Pubmed]
  7. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Grimbacher, B., Hutloff, A., Schlesier, M., Glocker, E., Warnatz, K., Dräger, R., Eibel, H., Fischer, B., Schäffer, A.A., Mages, H.W., Kroczek, R.A., Peter, H.H. Nat. Immunol. (2003) [Pubmed]
  8. Immunodeficiency due to a faulty interaction between T cells and B cells. Laman, J.D., Claassen, E., Noelle, R.J. Curr. Opin. Immunol. (1994) [Pubmed]
  9. Interleukin-10 for common variable immunodeficiency. Fuchs, D., Weiss, G., Murr, C., Wachter, H. Lancet (1993) [Pubmed]
  10. B-cell development: a comparison between mouse and man. Ghia, P., ten Boekel, E., Rolink, A.G., Melchers, F. Immunol. Today (1998) [Pubmed]
  11. Hereditary C2 deficiency associated with common variable immunodeficiency. Seligmann, M., Brouet, J.C., Sasportes, M. Ann. Intern. Med. (1979) [Pubmed]
  12. Decreased levels of total and reduced glutathione in CD4+ lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: possible immunopathogenic role of oxidative stress. Aukrust, P., Svardal, A.M., Müller, F., Lunden, B., Berge, R.K., Frøland, S.S. Blood (1995) [Pubmed]
  13. Reversible common variable immunodeficiency syndrome induced by phenytoin. Travin, M., Macris, N.T., Block, J.M., Schwimmer, D. Arch. Intern. Med. (1989) [Pubmed]
  14. Common variable immunodeficiency: a family study and therapeutic trial with cimetidine. Segal, R., Dayan, M., Epstein, N., Zecler, E., Peller, S., Michalevitch, R., Brautbar, C., Moses, E. J. Allergy Clin. Immunol. (1989) [Pubmed]
  15. Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen). Ambrus, J.L., Haneiwich, S., Chesky, L., McFarland, P., Engler, R.J. J. Allergy Clin. Immunol. (1991) [Pubmed]
  16. Shared HLA class II-associated genetic susceptibility and resistance, related to the HLA-DQB1 gene, in IgA deficiency and common variable immunodeficiency. Olerup, O., Smith, C.I., Björkander, J., Hammarström, L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Increased IL-6 gene expression and production in patients with common variable immunodeficiency. Pandolfi, F., Paganelli, R., Oliva, A., Quinti, I., Polidori, V., Fanales-Belasio, E., Guerra, E., Aiuti, F. Clin. Exp. Immunol. (1993) [Pubmed]
  18. Duodenal intraepithelial gamma/delta T cells and soluble CD8, neopterin, and beta 2-microglobulin in serum of IgA-deficient subjects with or without IgG subclass deficiency. Nilssen, D.E., Aukrust, P., Frøland, S.S., Müller, F., Fausa, O., Halstensen, T.S., Brandtzaeg, P. Clin. Exp. Immunol. (1993) [Pubmed]
  19. B cells from a distinct subset of patients with common variable immunodeficiency (CVID) have increased CD95 (Apo-1/fas), diminished CD38 expression, and undergo enhanced apoptosis. Saxon, A., Keld, B., Diaz-Sanchez, D., Guo, B.C., Sidell, N. Clin. Exp. Immunol. (1995) [Pubmed]
  20. Aberrant IgG subclass distribution to measles in healthy seropositive individuals, in patients with SSPE and in immunoglobulin-deficient patients. Mathiesen, T., Hammarström, L., Fridell, E., Linde, A., Wirsen, G., Smith, C.I., Norrby, E., Wahren, B. Clin. Exp. Immunol. (1990) [Pubmed]
  21. Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency. Warnatz, K., Bossaller, L., Salzer, U., Skrabl-Baumgartner, A., Schwinger, W., van der Burg, M., van Dongen, J.J., Orlowska-Volk, M., Knoth, R., Durandy, A., Draeger, R., Schlesier, M., Peter, H.H., Grimbacher, B. Blood (2006) [Pubmed]
  22. Human-human B cell hybridomas from in vitro stimulated lymphocytes of patients with common variable immunodeficiency. Denis, K.A., Wall, R., Saxon, A. J. Immunol. (1983) [Pubmed]
  23. Leukocyte circulation: one-way or round-trip? Lessons from primary immunodeficiency patients. Badolato, R. J. Leukoc. Biol. (2004) [Pubmed]
  24. Reduced interleukin-2 (IL-2) production in common variable immunodeficiency is due to a primary abnormality of CD4+ T cell differentiation. Eisenstein, E.M., Jaffe, J.S., Strober, W. J. Clin. Immunol. (1993) [Pubmed]
  25. Common variable immunodeficiency leading to spinal subacute combined degeneration monitored by MRI. Yousry, T.A., Strupp, M., Brüning, R. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
  26. CD58 (LFA-3) stimulation provides a signal for human isotype switching and IgE production distinct from CD40. Diaz-Sanchez, D., Chegini, S., Zhang, K., Saxon, A. J. Immunol. (1994) [Pubmed]
  27. Interleukin-4 suppresses immunoglobulin production by peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) induced by supernatants of T cell clones. Pastorelli, G., Roncarolo, M.G., Touraine, J.L., Rousset, F., Pene, J., de Vries, J.E. Clin. Exp. Immunol. (1989) [Pubmed]
  28. IL-10 production and CD40L expression in patients with common variable immunodeficiency. Oliva, A., Scala, E., Quinti, I., Paganelli, R., Ansotegui, I.J., Giovannetti, A., Pierdominici, M., Aiuti, F., Pandolfi, F. Scand. J. Immunol. (1997) [Pubmed]
  29. Common variable immunodeficiency and IgG subclass deficiency in central Alabama hemochromatosis probands homozygous for HFE C282Y. Barton, J.C., Bertoli, L.F., Acton, R.T. Blood Cells Mol. Dis. (2003) [Pubmed]
  30. HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama. Barton, J.C., Bertoli, L.F., Acton, R.T. BMC Med. Genet. (2003) [Pubmed]
  31. Intracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry. North, M.E., Ivory, K., Funauchi, M., Webster, A.D., Lane, A.C., Farrant, J. Clin. Exp. Immunol. (1996) [Pubmed]
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