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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effect of acidosis in hypokalemic periodic paralysis.

Metabolic acidosis was produced in two patients with hypokalemic periodic paralysis by the administration of ammonium chloride over a period of three days. The challenging test of glucose and insulin produced a substantially smaller reduction of both serum potassium concentration and muscle strength than when the patients were tested in normal acid-base balance. The findings agree with earlier work on acetazolamide, suggesting that metabolic acidosis provides protection against episodes of muscle weakness in periodic paralysis.[1]


  1. The effect of acidosis in hypokalemic periodic paralysis. Jarrell, M.A., Greer, M., Maren, T.H. Arch. Neurol. (1976) [Pubmed]
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