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Guay, D. et al.

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.[1]

References

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair. Guay, D., Gauthier, J.Y., Dufresne, C., Jones, T.R., McAuliffe, M., McFarlane, C., Metters, K.M., Prasit, P., Rochette, C., Roy, P., Sawyer, N., Zamboni, R. Bioorg. Med. Chem. Lett. (1998) [Pubmed]

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