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Chemical Compound Review

Singular     2-[1-[[(1R)-1-[3-[(E)-2-(7- chloroquinolin...

Synonyms: Brondilat, Montair, montelukast, CHEMBL787, Brondilat (TN), ...
 
 
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Disease relevance of montelukast

 

High impact information on montelukast

 

Chemical compound and disease context of montelukast

  • To evaluate the effect of low dose montelukast (MK) on the development of airway remodeling using a chronic murine model of allergic airway inflammation with subepithelial fibrosis, BALB/c mice, after intraperitoneal ovalbumin (OVA) sensitization on days 0 and 14, received intranasal OVA periodically on days 14-75 [1].
 

Analytical, diagnostic and therapeutic context of montelukast

  • This study was designed to assess asthma control, asthma-related quality of life, asthma-related emergency department (ED) visit/hospitalization, treatment-related satisfaction, and productivity losses in patients newly started on FSC or MON [3].

References

  1. The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model. Muz, M.H., Deveci, F., Bulut, Y., Ilhan, N., Yekeler, H., Turgut, T. Exp. Mol. Med. (2006) [Pubmed]
  2. Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients. Lee, D.K., Jackson, C.M., Haggart, K., Lipworth, B.J. Chest (2004) [Pubmed]
  3. Comparing outcomes in patients with persistent asthma: a registry of two therapeutic alternatives. O'Connor, R.D., Gilmore, A.S., Manjunath, R., Stanford, R.H., Legorreta, A.P., Jhingran, P.M. Current medical research and opinion. (2006) [Pubmed]
  4. Adherence to asthma controller medication regimens. Stempel, D.A., Stoloff, S.W., Carranza Rosenzweig, J.R., Stanford, R.H., Ryskina, K.L., Legorreta, A.P. Respiratory medicine. (2005) [Pubmed]
  5. The use of rhinitis medications in children receiving initial controller therapy for asthma. Stempel, D.A., Stanford, R.H., Carranza Rosenzweig, J.R., McLaughlin, T.P. Current medical research and opinion. (2006) [Pubmed]
 
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